DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Saturday 7 September 2013

Making HSQC look nicer « Naturalproductman’s Blog

HSQC

Making HSQC look nicer « Naturalproductman’s Blog:

'via Blog this'



 SHIRDI, MAHARASHTRA, INDIA

Shirdi - Wikipedia, the free encyclopedia

en.wikipedia.org/wiki/Shirdi
pronunciation (help·info) (Marathi: शिर्डी) is a town and falls under the jurisdiction of municipal council popularly known as Shirdi Nagar Panchayat, located ...


 Map of shirdi maharashtra.




 
 

 

 


 
 

 


 

 Shraddha Inn,Shirdi

 
 SHIRDI PRASADALAYA BOJAN

 


 Solar Kitchen Feeds Many at Shirdi, India Shrine

 

 


 Rajdhani Restaurant: Rajdhani at Shirdi

 

 The well equipped kitchen provides food two times a day, daily. Around 27, 000 of people are distributed food at cheap rate. The food comprises of dal, 

 
 





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Wednesday 4 September 2013

The Claimed Intermediate database by Tcipatent Ltd « New Drug Approvals

The Claimed Intermediate database by Tcipatent Ltd « New Drug Approvals:

'via Blog this'


Eddie Kehoe

Eddie Kehoe

Principal & Technical Director at Tcipatent Ltd
Hove, Brighton and Hove, United KingdomPharmaceuticalsThe Claimed Intermediate – a Structure Searchable Process Patent Database for Marketed Pharmaceutical Drugs (INNs).
Patent examining, searching, analysis and abstracting especially in the Chemical subject area.

          
The Claimed Intermediate is an online database
which covers Process Patents for Named Marketed Pharmaceutical Drugs – whether intermediates are claimed or not – for a low-cost subscription.
  • Structure Searchable
  • Includes INNs in at least one major Market
  • Includes Drug Synthesis often buried in a Plethora of Patents
  • Informs Pipeline decisions
  • Provides targeted Patent data in a Visual form
  • Informs Commercial Synthesis profitability
Click here for more information on our comprehensive solution
shared message from Eddie Kehoe
If anybody would like a trial of the database they could contact either myself eddie.kehoe@tcipatent.com, or my wife and fellow director, Pat Kehoe (pat.kehoe@tcipatent.com).
Here are temporary logons , please request trial
(deactivated automatically in five working days):
Link: Link: www.tcipatent.com/tcidb/
Structure Searchable Patent Database for Processes covering Named Marketed Pharmaceutical Drugs (INNs). The database is an ongoing Watching Service combined with a Backward Drug Service.
Eddie Kehoe
Principal & Technical Director
Tcipatent Ltd
www.tcipatent.com
info@tcipatent.om
tcipatent.com
Office: +44 (0)1273 736080
43 Farm Road, Hove, BN3 1FD, United Kingdom
Eddie Kehoe:
eddie.kehoe@tcipatent.com
Mobile – 07425629637
Skype – eddieskihoe
TWITTER-TCIPATENT
Pat Kehoe:
pat.kehoe@tcipatent.com
Mobile – 07585295531
Skype – patkehoe170348
Database Updates:
Recently Added Records
AliskirenAmbrisentan
AsenapineAtorvastatin
BosentanCabazitaxel
CefamandoleDasatinib
DesogestrelDexmedetomidine
DocetaxelDoripenem
DoxapramDuloxetine
EtonogestrelEtoricoxib
EtravirineFluvastatin
GefitinibIodixanol
IohexolIopamidol
LinagliptinMitiglinide
MontelukastMoxonidine
OseltamivirPaclitaxel
PerampanelPitavastatin
PravastatinPraziquantel
RitodrineRosuvastatin
SilodosinSitagliptin
TicagrelorUlipristal
Zidovudine
………..
photo

Coopers Cask - Pub in Hove BN3 1FB

Eddie is closeby

Tuesday 3 September 2013

TERIFLUNOMIDE SPECTRAL DATA


Teriflunomide,
HMR-1726, 1726, A-771726, RS-61980, SU-0020,
(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
108605-62-5, 282716-73-8 (monosodium salt)
C12-H9-F3-N2-O2 270.2091

SPECTROSCOPY DATA ]

 ! HNMR (DMSO, 300MHz) :δ 2.24(s, 3H); 5.36(bs, IH); 7.65(d, J=8.7Hz, 2H);
7.76(d, J=8.6Hz, 2H); 10.89(s, IH) ppm. 

13 CNMR (DMSO, 75MHz) :δ 23.5, 82.1, 118.3, 122.2, 126.5, 126.9, 142.1, 167.4,
187.8 ppm.
MS(FD) : m/e 269(M", 100).

 IR : 3305, 2220, 1633, 1596, 1554, 1418, 1405, 1325, 1247, 1114, 1157, 1073, 971,
842, 684 cm-1.
REF EP 2280938 A2





UPDATED


TERIFLUNOMIDE SPECTRAL DATA


Teriflunomide,
HMR-1726, 1726, A-771726, RS-61980, SU-0020,
(Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
108605-62-5, 282716-73-8 (monosodium salt)
C12-H9-F3-N2-O2 270.2091
17= US2011/0105795A1
NMR DASTA
1H NMR AND 13C NMR
1H NMR13C NMR
above 13C NMR
! HNMR (DMSO, 300MHz) :δ 2.24(s, 3H); 5.36(bs, IH); 7.65(d, J=8.7Hz, 2H);
7.76(d, J=8.6Hz, 2H); 10.89(s, IH) ppm.
13 CNMR (DMSO, 75MHz) :δ 23.5, 82.1, 118.3, 122.2, 126.5, 126.9, 142.1, 167.4,
187.8 ppm.
MS(FD) : m/e 269(M”, 100).
 IR : 3305, 2220, 1633, 1596, 1554, 1418, 1405, 1325, 1247, 1114, 1157, 1073, 971,
842, 684 cm-1.
REF EP 2280938 A2
Example-1  Preparation of Ethyl-2-cyano-3-hydroxy-but-2-enoate (III) [77] Potassium carbonate (73.3 g) was added to the well stirred solution of Ethylcy- anoacetate (50 g) in Dimethylformamide (250 ml) and stirred for 15 minute at ambient temperature. Acetic anhydride (90.25 g) was added drop wise to the above well stirred solution during 2 to 3 hours at ambient temperature. Reaction mixture was stirred at ambient temperature for 15 to 20 hours. Reaction mixture was diluted with water (500 ml) and extracted with dichloromethane (3 xlOO ml). Combined organic layer was washed with saturated sodium carbonate solution (3x100ml). Aqueous carbonate layer was separated and acidified with 50% HCl solution and extracted with dichloromethane (3x100ml). Combined organic layer was washed with brine solution (100 ml), dried over sodium sulfate and evaporated to yield Ethyl 2-cyano-3-hydroxy-but-2-enoate (58 g).
Yield: 84.6% Example-2 Preparation of Teriflunomide (I) [82] Ethyl 2-cyano-3-hydroxybut-2-enoate (III) (50 g) and 4-(trifluoromethyl) aniline (51.9 g) in xylene (1000 ml) was refluxed for 48 hours. The reaction mixture was allowed to cool at room temperature. Separated solid was filtered and washed with xylene (2×100 ml). Solid was dried under vacuum at 700C to yield (62 g) of Teri- flunomide.
Yield: 71.0%
Purity: 99.4%
! HNMR (DMSO, 300MHz) :δ 2.24(s, 3H); 5.36(bs, IH); 7.65(d, J=8.7Hz, 2H);
7.76(d, J=8.6Hz, 2H); 10.89(s, IH) ppm.
13 CNMR (DMSO, 75MHz) :δ 23.5, 82.1, 118.3,
122.2, 126.5,
126.9, 142.1, 167.4,
187.8 ppm.
MS(FD) : m/e 269(M”, 100).
IR : 3305, 2220, 1633, 1596, 1554, 1418, 1405, 1325, 1247, 1114, 1157, 1073, 971,
842, 684 cm-1.
1H NMR PREDICT
2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide NMR spectra analysis, Chemical CAS NO. 108605-62-5 NMR spectral analysis, 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide H-NMR spectrum
2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide NMR spectra analysis, Chemical CAS NO. 108605-62-5 NMR spectral analysis, 2-Cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide,teriflunomide C-NMR spectrum
COSY
COSY
HPLC
HPLC method of analysis:
N-(4′-trifluoromethylphenyI)-5-methylisoxazole-4-carboxamide of formula-2:
Apparatus: A liquid chromatographic system equipped with variable wavelength UV- detector; Column: Cosmicsil APT CI 8, 100 x 4.6 mm, 3 μιη (or) equivalent; Flow rate: 1.5 ml/min; Wavelength: 210 nm; Column Temperature: 25°C; Injection volume: 20 μί; Run time: 40 min; Diluent: Mobile phase; Needle wash: Tetrahydrofuran; Elution: Isocratic; Mobile phase: 5 ml of triethyl amine into a 650 ml of water. Adjusted the pH to 3.4 with dil. Orthophosphoric acid and filter this solution through 0.22 μπι nylon membrane filter paper and sonicate to degas it. (Z)-2-cyano-3-hydroxy-but-2-enoicacid-(4-trifluoromethyl phenyl)-amide compound of formula- 1:
Apparatus: A liquid chromatographic system equipped with variable wavelength UV- detector; Column: Kromasil 100 C18, 250 x 4.6 mm, 5 μηι (or) equivalent; Flow rate: 1.0 ml/min; Wavelength: 250 nm; Column Temperature: 35°C; Injection volume: 5 μί; Run time: 37 min; Diluent: 0.01 M dipotassium hydrogen orthophosphate in 1000 ml of water; Elution: Gradient; Mobile phase-A: Buffer (100%); Mobile phase-B: Acetonitrile : Buffer (70:30 v/v); Buffer: 1 ml of ortho phosphoric acid into a 1000 ml of water and 3.0 grams of 1 -octane sulfonic acid sodium salt anhydrous. Adjust pH to 6.0 with potassium hydroxide solution and filtered through 0.22μηι Nylon membrane filter paper and sonicate to degas it……..http://www.google.com/patents/WO2015029063A2?cl=en
WO2009147624A2*3 Jun 200910 Dec 2009Alembic LimitedA process for preparing teriflunomide
WO2011004282A2*22 Jun 201013 Jan 2011Alembic LimitedNovel polymorphic form of teriflunomide salts
US549491124 Oct 199027 Feb 1996Hoechst AktiengesellschaftIsoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
US56797097 Jun 199521 Oct 1997Hoechst AktiengesellschaftN-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide or salts, used for reduction of b-cell produced self-antibodies
US59901416 Jan 199523 Nov 1999Sugen Inc.Administering 5-methyl-isoxazole-4-carboxylic acid-n-(4-trifluoromethyl)anilide or 2-cyano-3-hydroxy-n-(4-trifluoro-methyl)phenyl-2-butenamide; antitumor,-carcinogenic and proliferative agents; kinase inhibitors
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