ORGANIC SPECTROSCOPY INTERNATIONAL: ZIPRASIDONE

Ziprasidone

CAS 146939-27-7

CAS Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one

Additional Names: 5-(2-(4-(1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chlorooxindole

Manufacturers' Codes: CP-88059

Molecular Formula: C21H21ClN4OS

Molecular Weight: 412.94

Percent Composition: C 61.08%, H 5.13%, Cl 8.59%, N 13.57%, O 3.87%, S 7.77%

Hydrochloride monohydrate

CAS Registry Number: 138982-67-9; 122883-93-6 (anhydrous)

Manufacturers' Codes: CP-88059-1

Trademarks: Geodon (Pfizer); Zeldox (Pfizer)

Molecular Formula: C21H21ClN4OS.HCl.H2O

Molecular Weight: 467.41

Percent Composition: C 53.96%, H 5.18%, Cl 15.17%, N 11.99%, O 6.85%, S 6.86%

Literature References: Prepn: D. J. M. Allen et al., EP 586191; eidem, US 5312925 (1993, 1994 both to Pfizer).

Properties: White to slightly pink powder. Also prepd as the hemihydrate, mp >300°.

Melting point: mp >300°

Therap-Cat: Antipsychotic.

SEE.........http://newdrugapprovals.org/2013/11/19/ziprasidone/

Ziprasidone (marketed as Geodon, Zeldox by Pfizer) was the fifth atypical antipsychotic to gain approval (February 2001) in the United States. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia, and acute mania and mixed states associated withbipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate.

Ziprasidone is also used off-label for depression, bipolar maintenance, mood disorders, anxiety, aggression, dementia, attention deficit hyperactivity disorder, obsessive compulsive disorder, autism, and post-traumatic stress disorder.