ORGANIC SPECTROSCOPY INTERNATIONAL: (Z)-methyl 3-(2-oxopyrrolidin-1-yl-3-phenylacrylate

(Z)-methyl 3-(2-oxopyrrolidin-l-vO-3-phenylacrylate (3a )

Ή NMR (400 MHz, CDC1₃) δ 7.47-7.38 (m, 5H), 6.27 (s, 1H), 3.75 (s, 3H), 3.55 (t, J = 7.0 Hz, 2H), 2.60 (t, J = 8.0 Hz, 2H), 2.22-2.15 (m, 2H);

¹³C NMR (100 MHz, CDC1₃) δ 175.35, 165.02, 148.23, 134.75, 130.60, 128.95, 127.06, 1 14.46, 51.59, 49.12, 31.68, 19.18;

HRMS (ESI) m/z [M+H]+: Calcd for Ci₄H,₆N0₃: 246.1 130 Found: 246.1 139.

(Z)methyl 3-(4-methoxyphenyl)-3- -oxopyrrolidin-l -yl acrylate (3 b)

Ή NMR (400 MHz, CDC1₃) δ 7.41 (d, J = 8.8 Hz, 2H), 6.91 (d, J = 8.8 Hz, 2H), 6.21 (s, 1H), 3.84 (s, 3H), 3.74 (s, 3H), 3.56 (t, J = 7.0 Hz, 2H), 2.60 (t, J = 8.0 Hz, 2H), 2.23-2.15 (m, 2H);

^,3C NMR (100 MHz, CDC1₃) δ 175.44, 165.13, 161.68, 148.32, 128.56, 126.94, 1 14.38, 1 12.38, 55.42, 51.46, 49.26, 31.72, 19.21 ;

HRMS (ESI) m/z [M+H]+: Calcd for Ci₅H,₈N0₄: 276.1236 Found: 276.1239.

http://www.google.com/patents/WO2012173572A1?cl=en

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