The chemical formulae of omeprazole, lansoprazole, rabeprazole and pantoprazole represented as:

Lansoprazole Pantoprazole

Pantoprazole

Select A Method:


	Pantoprazole Column: (R,R) or (S,S)-alpha-Burke 2 5 µm 25 cm x 4.6 mm Method: Chiral Separations by HPLC Regis Catalog Number: 1-735035-300; 1-735037-300 CAS#: 102625-70-7

	Pantoprazole Column: RegisPack 5 µm 25 cm x 4.6 mm Method: Chiral Separations by HPLC Regis Catalog Number: 1-783104-300 CAS#: 102625-70-7

	Pantoprazole Column: RegisPack, 5 µm, 25 cm x 4.6 mm Method: Chiral Separations by SFC Regis Catalog Number: 1-783104-300 CAS#: 102625-70-7

PANTOPRAZOLE

Title: Pantoprazole

CAS Registry Number: 102625-70-7

CAS Name: 5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

Manufacturers' Codes: SKF-96022; BY-1023

Molecular Formula: C16H15F2N3O4S

Molecular Weight: 383.37

Percent Composition: C 50.13%, H 3.94%, F 9.91%, N 10.96%, O 16.69%, S 8.36%

Literature References: Gastric proton pump inhibitor. Prepn: B. Kohl et al., EP 166287; eidem, US 4758579 (1986, 1988 both to Byk Gulden); eidem, J. Med. Chem. 35, 1049 (1992). Mechanism of action: W. A. Simon et al., Biochem. Pharmacol. 39, 1799 (1990). HPLC determn in plasma and serum: R. Huber et al., J. Chromatogr. 529, 389 (1990). Clinical pharmacokinetics: B. Simon et al., Z. Gastroenterol. 28, 443 (1990). Clinical trial in duodenal ulcer: P. Müller et al., ibid. 30, 771 (1992); in Zollinger-Ellison syndrome: E. A. Lew et al., Gastroenterology 118, 696 (2000). Review of pharmacology and clinical experience: P. Poole, Am. J. Health-Syst. Pharm. 58, 999-1008 (2001).

Properties: Off-white solid, mp 139-140° (dec). pKa1 3.92; pKa2 8.19.

Melting point: mp 139-140° (dec)

pKa: pKa1 3.92; pKa2 8.19

Derivative Type: Sodium salt

CAS Registry Number: 138786-67-1

Trademarks: Eupantol (Altana); Pantecta (Pfizer); Pantozol (Altana); Pantopan (Pharmacia); Pantorc (Altana); Peptazol (Recordati); Protium (Altana); Protonix (Wyeth); Somac (Pfizer)

Molecular Formula: C16H14F2N3NaO4S

Molecular Weight: 405.35

Percent Composition: C 47.41%, H 3.48%, F 9.37%, N 10.37%, Na 5.67%, O 15.79%, S 7.91%

Properties: Prepd as the sesquihydrate. White to off-white crystalline powder, dec >130°. uv max (methanol): 289 (e 1.64 ´ 104). Freely sol in water; very slightly sol in phosphate buffer (pH 7.4). Practically insol in n-hexane.

Absorption maximum: uv max (methanol): 289 (e 1.64 ´ 104)

Therap-Cat: Antiulcerative; in treatment of Zollinger-Ellison syndrome.

Keywords: Antiulcerative; Gastric Proton Pump Inhibitor.

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PESHAWAR, PAKISTAN FOOD

Peshawar is one the oldest cities of South Asia. It is an entrance point of Pakistan from the Afghanistan. It was an important city of Subcontinent and a meeting and marketing place for the public of Middle East, India and central Asia. Afghan warriors used this way to enter into subcontinent.