Solving Powder Structures Spectroscopy: Computational NMR approach deciphers what other methods cannot

 

The crystal structure of AZD8329 form 4 was determined using solid-state NMR.

http://cen.acs.org/articles/91/i45/Solving-Powder-Structures.html

Molecules can crystallize in different forms, which may have variable stability or solubility properties. For materials and pharmaceutical applications that use microcrystalline powders, manufacturers must be able to reliably produce specific crystal forms and have analytical methods available to ensure that they’re doing so.

http://cen.acs.org/articles/91/i45/Solving-Powder-Structures.html

NMR spectroscopy explained.pdf

NMR spectroscopy explained.pdf

Solid state NMR technique takes on Taxol

Taxol's active conformation has proved a puzzle

US scientists have developed a new technique for investigating the biologically active forms of the anticancer drug Taxol.

David Grant at the University of Utah, Salt Lake City, and co-workers have used novel solid state NMR techniques to establish the structure of a unique conformation of paclitaxel - more commonly known as Taxol.

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http://www.rsc.org/Publishing/ChemScience/Volume/2007/12/Taxol_NMR.asp