DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Thursday, 30 June 2016

Easy Preparation of Alkyl Amides

Simple method for making amides from alkyl iodides, amines, and a CO source

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A novel, mild and facile preparation of alkyl amides from unactivated alkyl iodides employing a fac-Ir(ppy)3-catalyzed radical aminocarbonylation protocol has been developed. Using a two-chambered system, alkyl iodides, fac-Ir(ppy)3, amines, reductants, and CO gas (released ex situ from Mo(CO)6), were combined and subjected to an initial radical reductive dehalogenation generating alkyl radicals, and a subsequent aminocarbonylation with amines affording a wide range of alkyl amides in moderate to excellent yields.

N-isopropylcyclohexanecarboxamide[2] (1a) (CAS 6335-52-0)
Prepared following the general procedure. Spectral data were in agreement with literature values. White solid (39 mg, 78%), Rf = 0.10 (10% EtOAc in n-pentane).

1H NMR (400 MHz, CDCl3): δ 5.19 (s, 1H), 4.07 (dt, J = 8.0, 6.6 Hz, 1H), 2.00 (tt, J = 11.7, 3.5 Hz, 1H), 1.89–1.72 (m, 4H), 1.74–1.52 (m, 1H), 1.48–1.35 (m, 2H), 1.31–1.18 (m, 3H), 1.13 (d, J = 6.6 Hz, 6H).

13C{1H} NMR (100 MHz, CDCl3): δ 175.4, 45.8, 41.1, 29.9, 25.9, 23.0. EI-MS: m/z 169.2.

2] O. Itsenko, T. Kihlberg, B. Långström, J. Org. Chem. 2004, 69, 4356–4360.



 Tenerife Island

Sunset at Tenerife Island — in Tenerife.




Map of Tenerife
Island in Spain
Tenerife, the largest of Spain’s Canary Islands, off West Africa, is dominated by Mt. Teide, which rises 7,500m above the ocean floor and is among the world’s largest volcanoes. Still, Tenerife may be best known for its huge pre-Lent Carnival, as well as its beaches (with sands from yellow to black) and busy, upscale resorts, including Los Cristianos and Playa de las Américas.



Candeleria church at tenerife

Tuesday, 28 June 2016

Butyl 1-methylindole-3-carboxylate

Heteronuclear multiple bond coherence (HMBC) spectrum of 3a
Butyl 1-methylindole-3-carboxylate
Molecular Formula:

Molecular Weight: 231.29028 g/mol


 Cres, Primorsko-Goranska, Croatia.





Menthyl 1-methylindole-3-carboxylate

Menthyl 1-methylindole-3-carboxylate



Portree,  scotland, uk