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Tuesday 21 June 2016

Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones

Graphical abstract: Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones.
 In search of developing new useful “click reactions”, herein we report the organocatalytic azomethine imine-olefin [3 + 2]-cycloaddition as a new click reaction for the synthesis of drug-like spiroindane-1,3-dione-pyrazolidinones from indane-1,3-diones, aldehydes and N,N-cyclic azomethine imines through amino acid-catalysis. The scope of this new click reaction is demonstrated using many examples with high reactivity, selectivity and yields.




 




 
Happy to share with you our recent work on the development of Tomita zipper-cyclization (TZC) reaction…I am sure that this reaction may become useful tool for organic chemists in near future…


Paper

Organocatalytic azomethine imine-olefin click reaction: high-yielding stereoselective synthesis of spiroindane-1,3-dione-pyrazolidinones

*Corresponding authors
a
School of Chemistry, University of Hyderabad, Hyderabad-500 046, India
E-mail: ramsc@uohyd.ac.in
Fax: +91-40-23012460
Org. Biomol. Chem., 2016, Advance Article

DOI: 10.1039/C6OB01009A http://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob01009a#!divAbstract





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Gargnano, Italy
 
Map of Gargnano Italy
Gargnano
Town in Italy
Gargnano is a town and comune in the province of Brescia, in Lombardy. It is situated on the western shore of Lake Garda. The municipal territory includes the artificial Valvestino Lake, created in 1962. Wikipedia
 
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