2-Chloro-2-methylpropanal , 2-クロロ-2-メチルプロパナル

2-Chloroisobutyraldehyde

• Molecular FormulaC₄H₇ClO
• Average mass106.551 

Propanal, 2-chloro-2-methyl- 

2-chloro-2-methylpropionaldehyde

917-93-1 [RN]

PROPANAL,2-CHLORO-2-METHYL-

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 3448, 1957 DOI: 10.1021/ja01570a036

2-Chloro-2-methylpropanal (4).(1)

Isobutyraldehyde (23.2 g, 0.32 mmol) was added to a two-neck round-bottom flask equipped with a magnetic stir bar, pressure equalizing funnel and reflux condenser. Sulfuryl chloride (33.8 g, 0.32 mmol) was then transferred to the addition funnel and added dropwise at a rate to maintain an external oil bath temperature below 40 °C. The evolved gases were vented through a trap containing water (ca. 50 mL). Once the sulfuryl chloride was added, the reaction was heated to 45 °C with stirring for 1.5 h then stirred at RT for an additional 2.5 h. The addition funnel and reflux condenser were replaced with a stopper and a distillation head fitted with a receiving flask. The crude material was distilled under a vacuum (95 °C, 115 mmHg). A second distillation was necessary to achieve the pure material as a colorless liquid (12.48 g, 37%). ¹H NMR (CDCl₃, 300 MHz) δ = 1.56–1.87 (m, 6 H), 9.42 (s, 1 H) ppm; ¹³C NMR (CDCl₃, 75 MHz) δ = 25.8, 69.3, 194.9 ppm.

REF  Stevens, C. L.; Gillis, B. T. J. Am. Chem. Soc. 1957, 79, 3448– 3451, DOI: 10.1021/ja01570a036

 

 

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Miramshah, Pakistan

Miramshah

Town in Pakistan

Miramshah, or Miranshah, is a town and administrative headquarters of the North Waziristan Agency in the Federally Administered Tribal Areas of Pakistan. Wikipedia

 
 

 
 

 

 
 
 
 

 

 
 
 
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