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Monday 31 August 2015

Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants

Rajesh Singh

M. Pharm., PhD, AIC
Professor (Assistant)
, Jalandhar · 


 

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 https://plus.google.com/115046907236504581005/about

 rksingh244@gmail.com

 

About

Dr Singh, educational qualifications from Panjab Univ., Chandigarh, GATE (2003) with 92.26 percentile, elected member of Association of Institution of Chemist (AIC), above 9 years of teaching experience and guided 16 PG students. He has to his credit > than 35 scientific research papers in reputed referred indexed journals, 40 res. presen., 1 book, 6 best paper presentation awards and 5 res. projects funded by PSCST, Chd. He is registered Pharmacist of Punjab State and life member of APTI.

Important pharmacophore of 1,4-benzodiazepine nucleus.
Figure 1.
Important pharmacophore of 1,4-benzodiazepine nucleus.




Synthesis of 2-amino-5-chloro-benzophenone derivatives (3a–3g)
Scheme 1.
Synthesis of 2-amino-5-chloro-benzophenone derivatives (3a3g)

2.3.3. 2-(4′-Chloroanilino)acetamido-5-chlorobenzophenone (3a)

IR (KBr cm−1): 3346 (Sec N–H str), 3100 (Aromatic C–H str), 2984 (Aliphatic C–H str), 1661 (Cdouble bond; length as m-dashO str), 1487 (Aromatic Cdouble bond; length as m-dashC str), 1229 (C–N str) and 761 (C–Cl str) 1H NMR (DMSO-d6 1δ ppm): 4.19 (s, 2H, –COCH2N), 7.26–8.60 (m, 12H, Ar–H) and 11.46 (br s, 1H, –NHCOCH2–) Anal. Calcd. for C21H16 N2O2Cl2: C, 63.17; H, 4.04; N, 7.02; Found: C, 63.07; H, 4.02; N, 7.09.

 1H NMR PREDICT






Volume 8, Issue 3, May 2015, Pages 307–312

Original article

Synthesis, physicochemical and biological evaluation of 2-amino-5-chlorobenzophenone derivatives as potent skeletal muscle relaxants

  • Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal, Rupnagar, Punjab 140126, India
Open Access funded by King Saud University
Under a Creative Commons license

Corresponding author. Tel.: +91 01887 221276, mobile: +91 9417513730; fax: +91 01887 221276   rksingh244@gmail.com
1 Present Address: Dept. of Pharmaceutical Chemistry, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, India.


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 Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal, Rupnagar, Punjab 140126, India












Dept. of Pharmaceutical Chemistry, Laureate Institute of Pharmacy, Kathog, Kangra, Himachal Pradesh, India.



















 Bhakra Dam, about 12 km from Nangal, the tallest dam of Asia









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