DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Friday, 24 June 2016

5-(hydroperoxymethyl)-2-phenyloxazole ....Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor

Abstract Image
The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temperature were performed, and the apparent activation energy for the oxidation reaction was determined. Elevated temperatures up to 100 °C and pressures up to 18 bar(a) led to a conversion rate of approximately 90% within 4 h of the reaction time, thus displaying the high potential and beneficial effect of using a microreactor setup with liquid recycle loop for this oxidation. The in situ reduction of the generated hydroperoxide functionality shows the capability of this setup for follow-up transformations.

5-(hydroperoxymethyl)-2-phenyloxazole
Oxazole–hydroperoxide 3as a colorless solid. Rf (PE/EA 3:1 = 0.31).
1H NMR (30 MHz, CDCl3) δ = 4.98 (s, 2H), 7.12 (s, 1H), 7.49–7.29 (m, 3H), 7.88–7.75 (m, 2H), 10.16 (s, 1H). GC-MS (EI) m/z = 173.1 (M – OH), 144.1 (M – CH2OOH), 116.1 (M – C6H5 + 2H), 89.1.

STR1

Safe and Fast Flow Synthesis of Functionalized Oxazoles with Molecular Oxygen in a Microstructured Reactor

 Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg,Germany
 Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany
§ Chemistry Department, Faculty of Science, King Abdulaziz University (KAU), 21589 Jeddah, Saudi Arabia
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.6b00118
*E-mail: t.roeder@hs-mannheim.de. Telephone: +49 621 292 6800.
Siegel
Organisch-Chemisches Institut                                     
Im Neuenheimer Feld 270
69120 Heidelberg
Germany
Institute of Chemical Process Engineering, Mannheim University of Applied Sciences, Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

Panorama picture of the Campus in July 2006

Thorsten Röder

Prof. Dr.
Professor (Full)

Research experience

  • Sep 2009–present
    Professor (Full)
    Hochschule Mannheim · Institute of Chemical Process Engineering
    Germany · Mannheim
  • Sep 2005–Aug 2009
    Laboratory Head
    Novartis · Chemical and Analytical Process Development
    Switzerland · Basel
  • Sep 1999–Aug 2004
    PhD Student
    Universität Paderborn · Department of Chemistry · Physical Chemistry Prof. Kitzerow
    Germany · Paderborn
 Teaching experience
  • Sep 2009–present
    Professor (Full)
    Hochschule Mannheim · Institute of Chemical Process Engineering
    Germany
    Lectures in: Chemical Reaction Engineering Thermodynamic Microreactors & Nanotechnology CFD Practical Course: Chemical Reaction Engineering

Education

  • Oct 1999–Oct 2004
    Universität Paderborn
    Physical Chemistry · Dr. rer. nat.
    Germany · Paderborn
  • Sep 1994–Sep 1999
    Universität Paderborn
    Chemistry · Diplom Chemiker
    Germany
Hashmi Stephen 160x200

Prof. Dr. A. Stephen K. Hashmi

E-Mail hashmi@hashmi.de
/////////Safe and Fast,  Flow Synthesis, Functionalized Oxazoles, Molecular Oxygen, Microstructured Reactor






TIBET FOOD
.























/////////

No comments:

Post a Comment