DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Thursday 2 June 2016

2, 6-dichloro-3 -methoxypyridine


Figure imgf000034_0001


Step 2 - Synthesis of 2, 6-dichloro- -methoxypyridine
To a solution of 2,6-dichloropyridin-3-ol (16.3 g, 0.1 mol) and K2C03 (41.4 g, 0.3 mol) in DMF (200 mL) were added Mel (21.3 g, 0.15 mol). The mixture was allowed to stir at 80 °C for 2 hours. The mixture was then diluted with water (200 mL) and extracted with EtOAc (200 mL x 3). The organic layer was washed with brine (200 mL x 3), dried over Na2S04, filtered and the solvent was concentrated in vacuo to provide 2,6-dichloro-3-methoxypyridine (17.0 g, yield: 96.0%).

 1H- NMR (CDC13;400 MHz) δ 7.12-7.18 (m, 2H), 3.86 (s, 3H).

 MS (M+H)+: 178 / 180 / 182.




///////

Jijiga, Ethiopia


Map of Jijiga Ethiopia
Jijiga
City in Ethiopia
Jijiga is a city in eastern Ethiopia and the capital of the Somali Region of the country. Located in the Jijiga Zone approximately 80 km east of Harar and 60 km west of the border with Somalia, this ... Wikipedia
 
 
 
 
 
 
 
 

 
 

 
 
 
 
 
 
//////////

No comments:

Post a Comment