Step 2 - Synthesis of 2, 6-dichloro- -methoxypyridine
To a solution of 2,6-dichloropyridin-3-ol (16.3 g, 0.1 mol) and K2C03 (41.4 g, 0.3 mol) in DMF (200 mL) were added Mel (21.3 g, 0.15 mol). The mixture was allowed to stir at 80 °C for 2 hours. The mixture was then diluted with water (200 mL) and extracted with EtOAc (200 mL x 3). The organic layer was washed with brine (200 mL x 3), dried over Na2S04, filtered and the solvent was concentrated in vacuo to provide 2,6-dichloro-3-methoxypyridine (17.0 g, yield: 96.0%).
1H- NMR (CDC13;400 MHz) δ 7.12-7.18 (m, 2H), 3.86 (s, 3H).
MS (M+H)+: 178 / 180 / 182.
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Jijiga, Ethiopia
Jijiga
City in Ethiopia
Jijiga
is a city in eastern Ethiopia and the capital of the Somali Region of
the country. Located in the Jijiga Zone approximately 80 km east of
Harar and 60 km west of the border with Somalia, this ... Wikipedia
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