1-IODOPROPANE

 1-IODOPROPANE

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  WORLDS BEST BEACHES




1. Le Grottes Plage, Costa Azul, France
Among popular  beaches in the globe, Le Grottes Plage is definitely worth a visit. Dotted with restaurants, this beach is a beach lover’s paradise.




2. Little Beach, Maui
Dotted with volcanic rock formations and dense shrubs, this beach is aparadise and is well known as the ‘unofficial clothing optional beach’.




3. Playa Las Suecas, Contadora Island, Panama
Among nudist beaches in the globe, this is an officialcolony where you are allowed to take off your clothing as and when you desire!




4. Lokrum Island, Dubrovnik, Croatia
A haven for those that love to bathe  this beach can be reached via boats and jetties. Rocky formations and sandy shore make this beach a paradise among nudists.




5. Haulover Beach, Florida, USA
This beach is counted as number five in this list of most popular beaches in the world because of its exotic beauty that enthralls its  bathers that come here to sun bathe in their most natural form.






6. Hedonism II, Negril, Jamaica
With a white sandy shoreline stretching 7 miles, this beach is a holiday maker’s Mecca and is visited, both by couples and families. It’s a passionate place where you can indulge in fulfilling many of your desires! Wink…Wink!




7. Black’s Beach, San Diego, United States
If visiting USA, make a visit to Black’s Beach that is one of most famous and beautiful beaches in the whole of United States. It is also a surfer’s paradise.




8. Montalivet Beach, France
The beach is famous for its  beach resort, the very place where international naturist movement started and boasts of 1800 campsites where you can take your clothes off and chill out.


9. Abrico Beach, Rio de Janeiro, Brazil
A bare all beach, it attracts nude bathers from all quarters of the globe. One can take part in a number of fitness programs here.


10. Club Orient, St. Martin, Caribbean
It is a famous resort and is counted among the world’s best  beaches simply because of its picturesque location and the presence of casinos and shopping arcades that make it a fun spot for tourists.



11. Arambol Beach, Goa, India
Armabol is a nudist’s favorite beach in India and is dotted with a rocky terrain and smooth waters.




12. Red Beach, Matala, Greece
When writing about world’s best  beaches, mention must be made of this exotic beach that used to be a haven for hippies in the late 60’s. Dotted with caves and ruins, this beach surely will enthrall all of you with its pristine beauty.



Image Credit: googleusercontent
13. El Torn Beach, Tarragona, Spain
Most popular among nude activists and lovers, this beach is one of the best beaches in Spain as bathers here can roam around wearing just about nothing, without having to give anyone an explanation!


14. Samurai Beach, Tomaree National Park, Australia
Drive down the beautiful Pacific Motorway, north of the capital city of Sydney to reach this awesome beach that is a hub for nude bathers that come here to play sports like volleyball and tug of war.


15. Plakias Beach, Crete, Greece
Plakias is Crete Island’s biggest beach that attracts  bathers and scuba divers from all across the planet.


16. Praia do Pinho Beach, Brazil
This beach is located in Santa Catarina and opened its doors to the nudists way back in 1987. From this beach, you can visit the world famous stature of Christ known as Cristo Luz.

Image Credit: travelchannel


17. Wreck Beach, Vancouver, Canada
The beautiful beach stretches to more than 7.8 km in length and is one of the world’s best beaches that is now counted as one of the seventh wonders of Canadaaaronvonhagen.




18. Spiaggia di Guvano, Corniglia, Italy
this beach can be reached once you cross the many caves that flank the shores.




19. Baker Beach, San Francisco, USA
San Francisco isn’t merely famous for its Golden Bridge, but attracts visitor to its rocky beach that offers majestic views of the bridge and is also a heaven for nude bathers. But it is only towards the end of the northern portion of this beach that you can sun bathe in the nude.






20. Moshup Beach, Massachusetts, USA
Known for its Bohemian styled sun bathers that come here to bathe and tan, this beach is accessible to nudists as well as others.







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5-Ethyl-7-hydroxy-2,2-dimethyl-4 H -benzo[ d ][1,3]dioxin-4-one

5-Ethyl-7-hydroxy-2,2-dimethyl-4 H -benzo[ d ][1,3]dioxin-4-one

  







PAPER
Total synthesis of the glycosylated macrolide antibiotic fidaxomicin
Org Lett 2015, 17(14): 3514
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b01602

The first enantioselective total synthesis of fidaxomicin, also known as tiacumicin B or lipiarmycin A3, is reported. This novel glycosylated macrolide antibiotic is used in the clinic for the treatment of Clostridium difficile infections. Key features of the synthesis involve a rapid and high-yielding access to the noviose, rhamnose, and orsellinic acid precursors; the first example of a β-selective noviosylation; an effective Suzuki coupling of highly functionalized substrates; and a ring-closing metathesis reaction of a noviosylated dienoate precursor. Careful selection of protecting groups allowed for a complete deprotection yielding totally synthetic fidaxomicin.

///////////// 5-Ethyl-7-hydroxy-2,2-dimethyl-4 H -benzo[ d ][1,3]dioxin-4-one

1-(1-((2′-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxy propan-2-yl)-2-propyl-1H-imidazol-5-yl)-3-methylbutan-1-one

Preparation of 1-(1-((2′-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxy propan-2-yl)-2-propyl-1H-imidazol-5-yl)-3-methylbutan-1-one (12)

Formic acid (50 mL) was added to a solution of 13 (10.0 g, 0.0137 mole) in methanol-acetonitrile (1 : 1, 150 mL) and heated to 50°C for 4 hours. The solution was cooled to room temperature, and the solvents were removed under reduced pressure. The residue was taken in water (100 mL) and extracted with ethyl acetate ( × 2 5 0 mL). The combined organic extracts were washed with 15% NaHCO3 solution (50 mL) and dried over anhydrous sodium sulfate. Evaporation of the solvents under reduced pressure at 55°C afforded crude 12which on purification by column chromatography on silica gel using 20% acetone in hexane afforded solid which on recrystallisation in n-heptane afforded pure 12 as a white solid (5.0 g, 75 %).

IR: (KBr, cm−1) 3409 (NH); 1664 (C=O); 1219 (Ar C–N); 1384, 1459 (Ar C=C); 1055.7, 957.7 (Ar C–H). 1H NMR: (DMSO-d6) 0.96 (t, 3H,  = 9 . 0and 7.2 Hz, CH3); 1.35 (s, 6H, 2CH3); 1.54 (s, 6H, 2CH3); 1.66 (m, 2H, CH2); 2.55 (t, 2H, J= 7.5 and 7.5 Hz, CH2); 4.31 (m, 1H, OH); 4.99 (s, 2H, CH2); 7.12–7.54 (m, 5H, Ar-H), ESI-MS: (m/z): 489, mp: 62–66°C, Elemental analysis: calculated for C80H92N18O9: C, 66.37; H, 6.60; N, 17.20; O, 9.82; found: C, 66.42; H, 6.73; N, 17.32; O, 9.97.

Scheme 4: Synthesis of olmesartan medoxomil unknown impurity (12).

Figure 6: Proposed structures of “unknown impurity (12) (M/Z: 488.58).”

Journal of Chemistry
Volume 2013 (2013), Article ID 516459, 8 pages
http://dx.doi.org/10.1155/2013/516459

Research Article

Synthesis and Characterization of Process-Related Impurities of Antihypertensive Drug Olmesartan Medoxomil

G. Venkanna,1,2 G. Madhusudhan,1 K. Mukkanti,2 A. Sankar,1 Y. Sampath Kumar,1 and G. Venakata Narayana1

1Department of Research and Development, Inogent Laboratories Private Limited, 28A, IDA, Nacharam, Hyderabad 500 076, India
2Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad 500 072, India

Received 18 February 2012; Accepted 17 May 2012

Academic Editor: Andreas G. Tzakos

Copyright © 2013 G. Venkanna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

http://www.hindawi.com/journals/jchem/2013/516459/sch4/
Olmesartan medoxomil (1) is the latest angiotensin receptor antagonist approved by the FDA for the treatment of hypertension. During the process development of olmesartan medoxomil, three process-related impurities were observed along with the final API. These impurities were identified as isopropyl olmesartan (12), dimedoxomil olmesartan (19), dibiphenyl olmesartan (17). The present work describes the synthesis and characterization of all these three impurities.

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