Methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

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Methyl (2S,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

Toluene (30 mL) was added to a round bottom flask and (2S,4R)-4-hydroxy-2-(methoxycarbonyl)pyrrolidin-1-ium chloride (5.30 g, 29.2 mmol) was suspended. The mixture was cooled down to 0°C. Firstly N,N-Diisopropylethylamine (DIPEA, 12.60 mL, 72.34 mmol, 2.48 equiv.) was added drop wise and then followed by benzyl bromide (3.80 mL, 31.92 mmol, 1.09 equiv.). The reaction mixture was refluxed for 6 h and quenched with saturated aqueous ammonium chloride solution (30 mL). The aqueous solution was extracted with ethyl acetate (3 × 150 mL). The combined organic layers were washed with brine (150 mL) and dried over sodium sulfate. Filtering of the drying agent and solvent removal under reduced pressure gave the product (6.74 g, 28.7 mmol, 98% yield) as yellowish oil. ¹H-NMR (CDCl₃, 300 MHz): δ = 1.75 (1H, br-s), 2.02–2,13 (1H, m), 2.18–2.33 (1H, m), 2.48 (1H, dd, J = 10.2, 3.7 Hz), 3.33 (1H, dd, J = 10.2, 5.6 Hz), 3.58–3.70 (2H, m), 3.66 (3H, s), 3.90 (1H, d, 12.9 Hz), 4.45 (1H, br-s), 7.20–7.38 (5H, m) ppm. ¹³C-NMR (CDCl₃, 75 MHz): δ = 39.6,51.9, 58.2, 61.3, 63.7, 70.4, 127.36, 128.4, 129.2, 138.2, 174.1 ppm. Analytic data agree with literature [v].

 Alza E, Sayalero S, Kasaplar P, Almasi D, Pericas MA (2011) Polystyrene supported diarylprolinol ethers as highly efficient organocatalysts for Michael-type reactions. Chem Eur J 17:11585–11595View Article

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 Oludeniz beach, Turkey

 

Oludeniz Beach

Oludeniz is Turkey's top beach destination and understandably is the most crowded. It is located on the south -west coast of Turkey in Fethiya town.

Famously known as the Turquoise Coast, the water here is an enchanting blue, and because the curved beach is so large, it can accommodate even the biggest crowds. There is beautiful mountain scenery and a blue lagoon with a large underwater park along the beach's western stretch.
The beach is surrounded by many resorts, especially the main hillside town of Belcekiz, which has crystal clear water, and a long shingle beach curving away from the town promenade. There are plenty of restaurants and caf�s where umbrellas and loungers can be hired. There are good hotels to stay at with added attractions like scuba diving; paragliding and hang gliding.
There are many other attractions at Olu Deniz like the picturesque Butterfly Valley, Saklikent Gorge, St Nicolas Island, or the Lycian Way.
Best time to visit Olu Deniz is from May to Oct. Summer temperature averages 32C while winters are pleasant with temperatures around 20C.
Dalaman about 30 miles away, is the closest airport. Local buses and taxis are available from the town of Fethiye which is seven miles away.
 

 
 

 

 


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Nanopalladium-catalyzed conjugate reduction of Michael acceptors - application in flow

Green Chem., 2016, 18,2632-2637
DOI: 10.1039/C5GC02920A, Communication

Anuja Nagendiran, Henrik Sorensen, Magnus J. Johansson, Cheuk-Wai Tai, Jan-E. Backvall
A continuous-flow approach towards the selective nanopalladium-catalyzed hydrogenation of the olefinic bond in various Michael acceptors, which could lead to a greener and more sustainable process, has been developed.

Nanopalladium-catalyzed conjugate reduction of Michael acceptors - application in flow

Communication

Nanopalladium-catalyzed conjugate reduction of Michael acceptors – application in flow

Anuja Nagendiran,^ab   Henrik Sörensen,^bc  Magnus J. Johansson,^bc   Cheuk-Wai Tai^d and   Jan-E. Bäckvall*^ab  

 

*Corresponding authors

^aDepartment of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden
E-mail: jeb@organ.su.se

^b

Berzelii Centre EXSELENT on Porous Materials, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden

^c

AstraZeneca R&D, Innovative Medicines, Cardiovascular and Metabolic Disorders, Medicinal Chemistry, Pepparedsleden 1, SE-431 83 Mölndal, Sweden

^d

Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91, Stockholm, Sweden

Green Chem., 2016,18, 2632-2637

DOI: 10.1039/C5GC02920A

http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C5GC02920A?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract
A continuous-flow approach towards the selective nanopalladium-catalyzed hydrogenation of the olefinic bond in various Michael acceptors, which could lead to a greener and more sustainable process, has been developed. The nanopalladium is supported on aminofunctionalized mesocellular foam. Both aromatic and aliphatic substrates, covering a variation of functional groups such as acids, aldehydes, esters, ketones, and nitriles were selectively hydrogenated in high to excellent yields using two different flow-devices (H-Cube® and Vapourtec). The catalyst was able to hydrogenate cinnamaldehyde continuously for 24 h (in total hydrogenating 19 g cinnanmaldehyde using 70 mg of catalyst in the H-cube®) without showing any significant decrease in activity or selectivity. Furthermore, the metal leaching of the catalyst was found to be very low (ppb amounts) in the two flow devices.






////////Nanopalladium-catalyzed,  conjugate reduction,  Michael acceptors, application,  flow  chemistry


Hvar Islands (Pakleni, Hvar Island)




























 


 

Kamp Nudist in Vrboska

Hvar has a strong naturist tradition, and Jerolim was named as CNN's top FKK beach for 2011. For the best comnbination of naturist camping and beaches, head through the pine trees to Kamp Nudist near Vrboska.

The history of naturism dates back to another British royal jumping in the water, this time Edward and Mrs. Simpson in the 1930s, when they received permission to bathe nude on the island of Rab. Naturism became very attractive in the 1960s with the emergence of mass tourism, and remains an important part of Croatia's tourism makeup, with more than a million naturist tourists last year, according to official figures.
Hidden from the rest of the tourists through the pine trees just outside Vrboska is the best option for a naturist holiday - the wonderful Kamp Nudist with adjoining beach. A new website for the camp will be launched soon (and we will bring it to you), but for now, enjoy the relaxed atmosphere of Hvar's premier naturist camp through the pictures below, and come on in - the water's lovely!

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