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Showing posts with label (-) SCLEROPHYTIN A. Show all posts
Showing posts with label (-) SCLEROPHYTIN A. Show all posts

Sunday 27 March 2016

(-) SCLEROPHYTIN A

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 ChemSpider 2D Image | (−)-Sclerophytin A | C20H34O4

 

(−)-Sclerophytin A

  • Molecular FormulaC20H34O4
  • Average mass338.482 Da
  • Monoisotopic mass338.245697 Da

 

5,12-Epoxybenzocyclodecene-6,9,10-triol, tetradecahydro-6,10-dimethyl-1-methylene-4-(1-methylethyl)-, (4R,4aR,5R,6R,9S,10S,12R,12aR)- [ACD/Index Name]
Sclerophytin A

 

Enantioselective Synthesis of (−)-Sclerophytin A by a Stereoconvergent Epoxide Hydrolysis

Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States
J. Am. Chem. Soc., 2010, 132 (46), pp 16380–16382
DOI: 10.1021/ja108185z......
 http://pubs.acs.org/doi/abs/10.1021/ja108185z
Abstract Image
The cytotoxic natural product (−)-sclerophytin A was constructed in 13 steps from geranial. Highlights from the synthesis are a stereoselective Oshima−Utimoto reaction, a Shibata−Baba indium-promoted radical cyclization, and a novel stereoconvergent epoxide hydrolysis.








 


 
//////// http://www.chem.ucla.edu/~jung/pdfs/215.pdf