[(3-cyano-5-phenyl -1H- pyrrol-2-yl) thio] acetic acid
(2-phenyl-2-oxoethyl) malononitrile (1. 0g, 54. 3mmol), methanol (150ml) and thioglycolic acid (6. 0g, 52. 6_〇1) loading into the reactor, and the mixture was heated at reflux for 0.5 hours. Let the mixture was cooled and stirred for 0.5 hours at room temperature and was stirred under ice-cooling 0.5 hours. The crystals were collected by filtration. With ethyl acetate (60ml) washing the wet crystals and reduced pressure, 50 ° C and dried to give the title compound (8. 8g, yield 60%).
i-NMRGOOMHz, TMS, DMS0-d6) δ (ppm):. 7 60 (d, J = 8. 0Hz, 2H), 7 39 (t, J = 7. 6Hz, 2H), 7.. 26-7. 21 (m, 1H), 6. 66 (s, 1H), 2. 51 (s, 2H).
high-resolution mass spectrometry (FAB) (C13H1QN202S)
calculated 257. 0835 [Μ-ΗΓ
measurements 257. 0390 [Μ-ΗΓ
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RAJKOT, GUJARAT, INDIA
Rajkot
City in India
Rajkot
is the fourth largest city in the state of Gujarat, India, after
Ahmedabad, Surat, and Vadodara. Rajkot is the center of the Saurashtra
region of Gujarat. Wikipedia
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