Olaparib オラパリブ 奥拉帕尼 (AZD-2281, trade name Lynparza)

Olaparib

オラパリブ

奥拉帕尼

syn.........http://newdrugapprovals.org/2014/12/19/olaparib-%E3%82%AA%E3%83%A9%E3%83%91%E3%83%AA%E3%83%96-azd-2281-trade-name-lynparza-az-first-in-class-parp-inhibitor-wins-eu-nod/

US 8183369

http://www.google.co.in/patents/US8183369

Mass Spectrum: MH+435

1H NMR (400 MHz. DMSO-d6) δ: 0.70 (m, 4H), 1.88 (br s, 1H), 3.20 (br s, 2H), 3.56 (m, 6H), 4.31 (s, 2H), 7.17 (t, 1H), 7.34 (dd, 1H), 7.41 (m, 1H), 7.77 (dt, 1H), 7.83 (dt, 1H), 7.92 (d, 1H), 8.25 (dd, 1H), 12.53 (s, 1H).

1H NMR spectrum of compound A (DMSO-d6) following the water treatment is shown in FIG. 1.

The powder XRD pattern of Compound A following the water treatment is shown in FIG. 2, which shows the compound is as Form A.

NMR PREDICTIONS

H-NMR spectral analysis

CAS NO. 763113-22-0, olaparib H-NMR spectral analysis

C-NMR spectral analysis

CAS NO. 763113-22-0, olaparib C-NMR spectral analysis