Posaconazole 泊沙康唑 بوساكونازول Позаконазол

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Posaconazole  泊沙康唑 ,  بوساكونازول , Позаконазол
Sch-56592
4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

1. Noxafil
2. SCH 56592

U.S. Patents 5,661,151; 5,703,079; and 6,958,337.

Therap-Cat: Antifungal.

CAS 171228-49-2

Molecular Formula: C37H42F2N8O4

Molecular Weight: 700.78

CAS Name: 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

Additional Names: (3R-cis)-4-[4-[4-[4-[5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-ylmethoxy]phenyl]piperazin-1-yl]phenyl]-2-[1(S)-ethyl-2(S)-hydroxypropyl]-3,4-dihydro-2H-1,2,4-triazol-3-one

Syn..........Dominic De Souza, "PREPARATION OF POSACONAZOLE INTERMEDIATES." U.S. Patent US20130203994, issued August 08, 2013.

Percent Composition: C 63.41%, H 6.04%, F 5.42%, N 15.99%, O 9.13%

US5661151   EXP Jul 19, 2019  PRODUCT PATENT

US 5703079  EXP Aug 26, 2014

US8410077 EXPMar 13, 2029

US9023790 EXPJul 4, 2031

US 6958337 EXP Oct 5, 2018

US 8263600 EXPApr 1, 2022

nmr...........http://file.selleckchem.com/downloads/nmr/s125705-posaconazole-cdcl3-hnmr-selleck.pdf

1H NMR PREDICT

13C NMR PREDICT

COSY PREDICT

............................

 tetrahydroimidazole,

4

 












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CN101824009A *

May 27, 2010

Sep 8, 2010

北京德众万全药物技术开发有限公司

Simple preparation method for posaconazole and piperazine intermediate thereof

Citing Patent	Filing date	Publication date	Applicant	Title
WO2015011224A1 *	Jul 24, 2014	Jan 29, 2015	Sandoz Ag	Improved process for the preparation of crystalline form iv of posaconazole

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