DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label 1-(2-Aminopropyl)-2-pyrrolidinone. Show all posts
Showing posts with label 1-(2-Aminopropyl)-2-pyrrolidinone. Show all posts

Tuesday 12 August 2014

1-(2-Aminopropyl)-2-pyrrolidinone

1-(2-Aminopropyl)-2-pyrrolidinone
Figure US20020052370A1-20020502-C00119



[0511] A mixture of the oxime from preparation 17 (375 mg, 2.40 mmol) and platinum oxide (300 mg) in ethanol (20 ml) was hydrogenated at 60 psi and room temperature for 18 hours. Tlc analysis showed starting material remaining, so additional platinum oxide (100 mg) was added and the reaction continued for a further 4 hours. The mixture was filtered through Arbocel®, and the filtrate evaporated under reduced pressure. The crude product was purified by column chromatography on silica gel using an elution gradient of dichloromethane:methanol:0.88 ammonia (95:5:0.5 to 90:10:1) to give the title compound as a clear oil, 170 mg, 50%; 

1H NMR (CDCl3, 400 MHz)
δ: 1.02 (d, 3H), 1.36 (bs, 2H), 2.00 (m, 2H), 2.38 (t, 2H), 3.00-3.16 (m, 2H), 3.21 (m, 1H), 3.35-3.45 (m, 2H); 

LRMS: m/z 143 (MH+).