DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label 1-(2-Chloropyridin-3-yl)ethanol. Show all posts
Showing posts with label 1-(2-Chloropyridin-3-yl)ethanol. Show all posts

Saturday 22 August 2015

1-(2-Chloropyridin-3-yl)ethanol

Figure imgf000077_0001



Step 1 : l-(2-Chloropyridin-3-yl)ethanol.
Figure imgf000077_0001
Dry THF (400 mL) and n-butyllithium (1.6 M in hexane, 63 mL, 0.1 mol) were introduced into a IL flask under nitrogen at -700C. A solution of dry diisopropylamine (10.1 g, 0.1 mol) in THF (25 mL) was added dropwise to the mixture at -70 0C. The mixture was then kept for 1 h at 0 0C and then cooled to -70 0C. A solution of 2- chloropyridine (11.3 g, 0.1 mol) in THF (25 mL) was added dropwise to the mixture at - 70 0C and the mixture was stirred for 3 h at this temperature. A solution of acetaldehyde (4.85 g, 0.11 mol) in dry THF (50 mL) was then added dropwise and the mixture was kept for 3 h at -70 0C. A solution of water (4 mL) in THF (40 mL), acidified by a few drops of concentrated hydrochloric acid, was added to the mixture at -40 0C and then water (200 mL) was introduced at -10 0C. Extraction with diethyl ether (3x150 mL), drying over anhydrous sodium sulfate, and evaporation gave a crude product, which was purified by column chromatography to yield an oil (10 g, 64%). 
*1H NMR (CDCl3) 8.15 (dd, J = 5 and 2 Hz, 1 H), 7.95 (dd, J = 8 and 2 Hz, 1 H), 7.20 (dd, J = 8 and 5 Hz, 1 H), 5.15 (d, J = 7 Hz, 1 H), 3.90 (s, 1 H), 1.45 (d, J = 7 Hz, 3 H).




* NMR values reported in Journal of Chemical Society Perkin Trans 1 : Organic and Bio-organic Chemistry, 1990, 9, 2409-2415.


 सुकून उतना ही देना प्रभू, जितने से जिंदगी चल जाये। औकात बस इतनी देना, कि औरों का भला हो जाये।
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO …..FOR BLOG HOME CLICK HERE


Join me on Linkedin

View Anthony Melvin Crasto Ph.D's profile on LinkedIn

Join me on Facebook FACEBOOK
Join me on twitterFollow amcrasto on Twitter
Join me on google plus Googleplus
Join me on Researchgate

Anthony Melvin Crasto Dr.

  amcrasto@gmail.com

09b37-misc2b027LIONEL MY SON
He was only in first standard in school when I was hit by a deadly one in a million spine stroke called acute transverse mylitis, it made me 90% paralysed and bound to a wheel chair, Now I keep him as my source of inspiration and helping millions, thanks to millions of my readers who keep me going and help me to keep my son happy


सुकून उतना ही देना प्रभू, जितने से
जिंदगी चल जाये।
औकात बस इतनी देना,
कि औरों का भला हो जाये।
Read all about Organic Spectroscopy on ORGANIC SPECTROSCOPY INTERNATIONAL  

/////