1-(2-Oxopropyl)-2-pyrrolidinone
[0487] Methylmagnesium chloride (2.7 ml, 3M in tetrahydrofuran, 8.1 mmol) was added to a cooled (−20° C.) solution of the amide from preparation 15 (1.5 g, 8.1 mmol) in tetrahydrofuran (50 ml), and the reaction allowed to warm to room temperature, then stirred for an hour. The mixture was quenched by the addition of aqueous ammonium chloride solution, then extracted with ethyl acetate (3×50 ml). The combined organic solutions were dried (MgSO4), and evaporated under reduced pressure to give the title compound as an oil, 645 mg, 56%;
1H NMR (CDCl3, 400 MHz) δ: 2.07 (m, 2H), 2.17 (s, 3H), 2.42 (t, 2H), 3.42 (t, 2H), 4.10 (s, 2H).
