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Showing posts with label 1-CYCLOPROPYLANTHRACENE. Show all posts
Showing posts with label 1-CYCLOPROPYLANTHRACENE. Show all posts

Friday, 17 June 2016

1-CYCLOPROPYLANTHRACENE



 



 




During the past years, Feringa and co-workers have developed very efficient palladium-catalyzed methodologies for the cross-coupling of organolithium reagents. 
They have now described that nickel-based catalytic systems are also able to successfully cross-couple these organometallic reagents to a variety of (hetero)aryl electrophiles ( Chem. Eur. J. 2016, 22, 3991). 
The reactions take place in toluene at room temperature with a 50% molar excess of the organolithium reagent and are usually finished within an hour. 
In order to limit the formation of reduced (hetero)aryl electrophile, a different catalyst has to be used for the efficient coupling of aryl- or alkyl-lithium reagents, a N-heterocyclic carbene ligated one (C3 above) for the former and bis(diethyldiphosphino)ethane ligated one (C1 above) for the latter. 
While the substrate scope appears to be limited by the high reactivity of the organometallic partner, these nickel-catalyzed protocols allow a number of less usual electrophiles, such as methyl ethers or fluorides, to engage in the cross-coupling reaction.
 See original article

Homogeous Catalysis

Nickel-Catalyzed Cross-Coupling of Organolithium Reagents with (Hetero)Aryl Electrophiles (pages 3991–3995)Dorus Heijnen, Dr. Jean-Baptiste Gualtierotti, Dr. Valentín Hornillos and Prof. Dr. Ben L. Feringa
Version of Record online: 4 FEB 2016 | DOI: 10.1002/chem.201505106
Thumbnail image of graphical abstract
Nickel-catalyzed cross-coupling of aromatic electrophiles with organolithium reagents is presented. The use of a commercially available nickel N-heterocyclic carbene complex allows reaction with a variety of (hetero)aryllithium compounds, whereas a commercially available electron-rich nickel bisphosphine complex smoothly converts alkyllithium species into the corresponding coupled product.

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Dajia, Murugan Kaliyappan, Taichung,



 Photo of Taichung Xingwu Shou Yanwuchang
 ung Zip Chemical would like to further strengthen their R&D abilities, integrate the laboratory's achievement with actually mass-produce in produce line and hope our new products could successful enter the market as soon as possible, so Yung Zip invests such amount to make replacements of facilities and upgrade the equipments, enable us to appear our R&D's achievements, that's the reasons                                                              why we strengthen our pilot plant.

Science and technology is changing with each passing day, cease making progress is equal to



do less well than before, due to the R&D news products influences the life and death ofa company, we are enthusiastic to enhance our R&D and employ many professional persons to enter our R&D teams.


The increasing of new facilities and upgrading equipments of pilot plant is the foundation for Yung Zip to expand its business scope in photoelectron domain, also combines with modernized management, Yung Zip has a strong background forward to its brightness future.


 



 Dajia, Taichung


 

 

 



 


 

 
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