1-Cyanocyclopropanecarboxylic acid ethyl ester
To a stirred solution of ethyl cyanoacetate (3 g, 26.53 mmol) in ethanol (30 mL), was added sodium ethoxide (4.51 g, 66.33 mmol) portionwise at 20 °C over 0.5 h followed by 1,2- dibromoethane (7.47 g, 39.8 mmol). The reaction mixture then was heated and stirred at reflux for 3.5 h. After concentration under vacuum, the residue was diluted with ethyl acetate (30 mL) and neutralized with aq. HCl (10 mL). The organic layer was separated and the aqueous layer extracted with ethyl acetate (2 × 15 mL). The combined organic extracts were dried over anhydrous Na2SO4 and concentrated at 40 °C under vacuum. The product was purified by column chromatography using hexane - EtOAc as eluent to yield the title compound as a colorless liquid (2.58 g, yield 70%);
REACTANTS
ETHYL CYANOACETATE
1,2 DIBROMOETHANE.......................................................................
1-Cyanocyclopropanecarboxylic acid ethyl ester
1H NMR (CDCl3, 300 MHz):
δ 1.34 (t, J = 7.1 Hz, 3H, CH3CH2O-), METHYL OF ETHYL ESTER
1.62 (t, J = 3.8 Hz, 2H, CH2 c-propyl), CYCLOPROPYL
1.67 (t, J = 3.8 Hz, 2H, CH2 c-propyl), CYCLOPROPYL
4.25 (q, J = 7.1 Hz, 2H, CH3CH2O-); CH2 OF ETHYLESTER
MS (CI): 162 (M+Na, 100%);
IR (neat, cm−1 ): 2986,
2249, NITRILE,
1736, ESTER,
1371, 1311, 1162, 1024, 971, 858, 747;
Elemental Analysis found: C, 60.30; H, 6.39; N, 10.24 C7H9NO2 Requires C, 60.42; H, 6.52; N, 10.07.
13 C NMR PREDICTIONS
COSY
DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE
Join me on twitter
Join me on google plus 
Googleplus
Googleplus
amcrasto@gmail.com
LIONEL MY SON
He was only in first standard in school when I was hit by a deadly one in a million spine stroke called acute transverse mylitis, it made me 90% paralysed and bound to a wheel chair, Now I keep him as my source of inspiration and helping millions, thanks to millions of my readers who keep me going and help me to keep my son happy
TAKE A TOUR
FUNK ISLAND, Canada
.Funk Island - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Funk_Island
Funk Island is a small, barren, isolated, uninhabited island approximately 60 kilometres (37 mi) northeast of Wesleyville, Newfoundland, Canada. Funk Island is ...
END
INDIAN CUISINE
Take a tour Indian food
Indian cuisine - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Indian_cuisineIndian cuisine encompasses a wide variety of regional cuisines native to India. Given the range of diversity in soil type, climate and occupations, these cuisines ...
Chennai – The King of Breakfast
SAMOSA
.
THALI
/////////
