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Showing posts with label 3-f] [l. Show all posts
Showing posts with label 3-f] [l. Show all posts

Tuesday 16 September 2014

Methyl thieno [2,3-f] [l, 3] benzodioxole-6-carboxylate

Methyl thieno [2,3-f] [l, 3] benzodioxole-6-carboxylate



Figure imgf000041_0002
Starting from 3.0 g (13.1 mmol) 6-Brompiperonal with 0.79 g (19.7 mmol) of sodium hydride (60% strength) and 1.53 g (14.4 mmol) mercaptoacetate 732 mg (18.5% o of theory) of the title compound.


1H NMR (200 MHz, DMSO-d 6):
 δ = 8.03 (s, IH), 
7.62 (s, IH), 
7.48 (s, IH), 
6.14 (s, 2H), 
3.86 (s, 3H) ppm 
.
HPLC: R t = 4.6 min (Method H) 

MS (ESIpos): + m / z = 237 (M + H)


http://www.google.com/patents/EP1461335A1?cl=en