4-((3,4-Dimethoxyphenylamino)methyl)-N-(2-amino-5-cyanophenyl)benzamide

 


http://www.google.com/patents/US7868205

 Example 55

4-((3,4-Dimethoxyphenylamino)methyl)-N-(2-amino-5-cyanophenyl)benzamide (199)

Step 1: 4-((3,4-Dimethoxyphenylamino)methyl)-N-(2-amino-5-cyanophenyl)benzamide (199) Following the same procedure as described in Example 27, step 2 (scheme 20), the title compound 199 was obtained in 16% yield.  


¹H NMR: (DMSO)
δ (ppm): 9.56 (bs, 1H),
7.89 (d, J=8.0 Hz, 2H),
7.52 (bs, 1H),
7.45 (d, J=8.4 Hz, 2H),
6.77 (d, J=8.4 Hz, 1H),
6.63 (d, J=8.4 Hz, 1H),
6.30 (d, J=2.4 Hz, 1H),
5.99-5.95 (m, 2H),
5.74 (bs, 1H),
4.92 (bs, 2H),
3.64 (s, 3H),
3.32 (s, 3H).


MS: (calc); 402.5 (obt.) 403.4 (MH)⁺.

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