4-Chlorobenzo[b]thiophene-2-carboxylic Acid

4-Chlorobenzo[b]thiophene-2-carboxylic acid; 23967-57-9; 4-chloro-1-benzothiophene-2-carboxylic acid; GA-0943; 4-chloro-benzo[b]thiophene-2-carboxylic acid;

4-Chlorobenzo[b]thiophene-2-carboxylic Acid 

 4 as a white solid

mp 260 °C.

1H NMR (300 MHz, DMSO-d6) δ 7.54 (d, 1H, J = 11.6, 7.7 Hz), 7.56 (dd, 1H, J = 17.8, 7.7 Hz), 8.03 (d, 1H, J = 0.7 Hz), 8.07 (td, 1H, J = 7.6, 0.9 Hz), 13.19 (brs, 1H).

13C NMR (75 MHz, DMSO-d6) δ 122.21, 125.01, 126.84, 127.99, 128.96, 136.50, 136.57, 142.55, 163.10.

Elemental analysis calcd for C: 50.83%, H: 2.37%, found C: 50.84%, H: 2.21%.

SEE

http://pubs.acs.org/doi/abs/10.1021/acs.oprd.5b00340

http://pubs.acs.org/doi/suppl/10.1021/acs.oprd.5b00340/suppl_file/op5b00340_si_001.pdf

Safe and Efficient Decarboxylation Process: A Practical Synthetic Route to 4-Chlorobenzo[b]thiophene

Masahiro Miyake^*, Masamichi Shimizu, Koichi Tsuji, and Keiichi Ikeda

Bulk Pharmaceutical Chemicals Department, Second Tokushima Factory, Production Headquarters, Otsuka Pharmaceutical Co., Ltd., 224-18, Hiraishi Ebisuno, Kawauchi-cho, Tokushima 771-0182, Japan

Org. Process Res. Dev., Article ASAP

DOI: 10.1021/acs.oprd.5b00340