PATENT
CN109053652-PREPARATION METHOD OF AMIODARONE HYDROCHLORIDE INTERMITTENT
https://patentscope.wipo.int/search/en/detail.jsf?docId=CN235615504&_cid=P11-KL0AU0-06410-1
Description of the drawings |
Figure 3 shows the proton nuclear magnetic resonance spectrum of compound 9; |
Figure 4 shows the carbon nuclear magnetic resonance spectrum of compound 9. |
compound 9 as an off-white crystalline powder with a yield of about 86.9%. |
1 HNMR(400MHz,d 1.24~1.29(m,2H,-CH 2.82~2.85(t,2H,Ar-CH 10.46(m,1H,-OH). 13 CNMR(400 Hz,DMSO)δ:189.72,163.49,162.69,153.48,132.08, 130.16,127.28,124.87,123.98 ,121.16,116.90,11 5.78, 111.51,29.94,27.51,22.09,13.84. See attached drawings 3~4. |
FTIR spectra of Amiodarone, Pluronic F68 and their solid dispersion formulations. ...https://www.japsonline.com/admin/php/uploads/2119_pdf.pdf
MAGNETIC RESONANCE IN CHEMISTRY, VOL. 29, 482493 (1991) 'H and 13C NMR Analyses of Amiodarone, Desethylamiodarone and Desoxoamiodarone
Amiodarone (AMIO) is an antianginal and antiarrhythmic drug used clinically to treat a wide range of
cardiac arrhythmias.',' Desethylamiodarone (DEA) is
the major metabolite of amiodarone,' and desoxoamiodarone (DOA) is reported to be a less toxic form of
ami~daro
Figure 2. 500-MHz ‘H 2D COSY NMR spectra showing the spin connectivities in (A) the aliphatic region of AMIO, (B) the aliphatic region of DEA, (C) the aliphatic region of DOA and (D) the aromatic region of AMIO. Note the similarity of the COSY patterns of AMIO, DEA and DOA.
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