DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label Ixazomib; MLN-9708.. Show all posts
Showing posts with label Ixazomib; MLN-9708.. Show all posts

Wednesday 11 February 2015

Ixazomib; MLN-9708.

CAS#:  1201902-80-8
Synonym:   Ixazomib; MLN-9708.
IUPAC/Chemical name: 
4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid
synthesis..........http://newdrugapprovals.org/2013/05/24/takeda-begins-phase-iii-trial-of-ixazomib-multiple-myeloma-drug/

Example 1: Synthesis of 4-(/?,S)-(carboxymethyl)-2-( (R)-I -(2-(2,5- dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-l,3,2-dioxaborinane-4- carboxylic acid (1-1)
Figure imgf000062_0001


Form 1 as a crystalline solid (6.65 g, 88 %). 

1H NMR (500 MHz, DMSOd6, δ 110 0C): 
10.08 (s, IH), 8.69 (s, IH), 
7.61 (s, IH), 
7.52 (d, J = 1.3 Hz, 2H), 
4.26 (d, J = 5.5 Hz, 2H), 
2.70 (q, J = 14.5 Hz, 4H), 
2.70 (bs, IH), 
1.72 (sept, J – 6.5 Hz, IH), 
1.42 (ddd, J = 5.2 Hz, J = 8.6 Hz, J = 13.9 Hz, IH), 
1.28 (ddd, J = 5.3, J = 9.4 Hz, J = 14.3 Hz, IH), 
0.91 (dd, J = 3.3 Hz, J = 6.6 Hz, 6H). 

MS (m/z) in CH3CN: [M+Na] calculated for C20H23BCl2N2NaO9, 539.1; found, 539.1.




Share this:

 COCK WILL TEACH YOU

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Join me on Linkedin

View Anthony Melvin Crasto Ph.D's profile on LinkedIn

Join me on Facebook FACEBOOK
Join me on twitterFollow amcrasto on Twitter     
Join me on google plus Googleplus

 amcrasto@gmail.com


DHAKA BANGLADESH

.
Steamers and ferries in Sadarghat Port
Kawran Bazar
.
Dry fish sellers at the Karwan Dry Fish Market (Bazar), Dhaka, Bangladesh.