Ethyl 2-((Z)-2, 4-dioxo-5-((1, 3-diphenyl-1H-pyrazol-4-yl)methylene)thiazolidin-3-yl)acetate (4a)
IR (νmax, KBr) cm-1: 1736, 1690, 1612, 1535, 1504, 1450, 1373, 1311, 1227, 1142, 1103, 1065, 1026.
1H NMR (CDCl3,
400 MHz, δ): 8.213 (s, 1H, Pyrazolyl H), 7.963 (s, 1H, =CH),
7.817-7.795 (m, 2H, Ar H), 7.678-7.654 (m, 2H, Ar H), 7.549-7.471 (m,
5H, Ar H), 7.414-7.377 (m, 1H, Ar H), 4.473 (s, 2H, NCH2), 4.275-4.222 (q, 2H, -OCH2CH3), 1.319-1.283 (t, 3H, -OCH2CH3).
MS (ESI+) m/z 434 [M+H].
Anal. Found: C, 63.3; H, 4.6; N, 9.5. C23H19N3O4S requires C, 63.73; H, 4.42; N, 9.69%.
http://orgmedchemlett.springeropen.com/articles/10.1186/2191-2858-1-15
Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents
- Deepak K AnejaEmail author,
- Poonam Lohan,
- Sanjiv Arora,
- Chetan Sharma,
- Kamal R Aneja and
- Om Prakash†
†Contributed equally
Organic and Medicinal Chemistry Letters20111:15
DOI: 10.1186/2191-2858-1-15
© Aneja et al; licensee Springer. 2011
Received: 14 July 2011
Accepted: 8 November 2011
Published: 8 November 2011
Abstract
Background
Thiazolidine-2, 4-diones (TZDs) have become a pharmacologically important class of heterocyclic compounds since their introduction in the form of glitazones into the clinical use for the treatment of type 2 diabetes. TZDs lower the plasma glucose levels by acting as ligands for gamma peroxisome proliferators-activated receptors. In addition, this class of heterocyclic compounds possesses various other biological activities such as antihyperglycemic, antimicrobial, anti-inflammatory, anticonvulsant, insecticidal, etc. TZDs are also known for lowering the blood pressure thereby reducing the chances of heart failure and micro-albuminuria in the patients with type 2 diabetes////////
Lào Cai Railway Station, vietnam, lao cai
Lao Cai Province
Vietnamese province
Lào
Cai is a province in the northwest of Vietnam. It’s known for its
mountains, rivers, waterfalls and ethnic hill tribes. The province's
towering peaks include Fansipan and dragon-jaw-shaped Hàm Rồng Mountain,
which offers panoramic views and gardens with hundreds of orchids. The
town of Sa Pa, in the Hoàng Liên Son mountains, overlooks the terraced
rice fields and ancient stone engravings of the Muong Hoa Valley.
