SPECTRAL DATA FOR RABEPRAZOLE SODIUM

SPECTRAL DATA FOR RABEPRAZOLE SODIUM
EP 1869015 B1
 IR Spectra (KBr, cm^-1): 3382, 2927, 1583, 1462, 1384, 1298, 1269, 1190, 1157, 1093, 1018, 745.

H NMR Spectra [200 M Hz, CD3OD] δ (ppm): 8.23 – 8.25 (1H, d, ArH); 7.57 – 7.62 (2H, m, ArH); 7.0 – 7.09 (2H, m, ArH); 6.87 – 6.90 (1H, d, ArH); 4.57 – 4.63 (2H, d, O=S-CH2-Ar); 4.0 – 4.1 (2H, t, -O-CH2-CH2-); 3.49 – 3.55 (2H, t, -CH2-O-CH3); 3.31 (3H, s, -OCH3); 2.1 (3H, s, Ar-CH3); 1.96 – 2.0 (2H, t, -CH2-CH2-CH2-).
.......................................................

¹H NMR (300 MHz, DMSO-d6) δ (ppm): 8.26-8.24 (d, 1H); 7.48-7.44 (m, 2H); 6.92-6.87 (m, 3H); 4.70-4.66 (d, 1H); 4.45-4.41 (d, 1H); 4.09-4.05 (t, 2H); 3.48-3.44 (t, 2H); 3.23 (s, 3H); 2.14 (s, 3H); 1.99-1.93 (q, 2H).
 US 8143409 B2
...........................................................


ONE MORE SOURCE FOR SODIUM RABEPRAZOLE DATA http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf

 IR (KBr, cm-1) 3047 (Ar-H), 2881(Ali-H), 1583 (aromatic
C=C), 1298 (C-N), 1093 (C-O arylalkylether),1027 (S-O,sulphoxide), 745 (Ar-H bending);

MS( ESI)+ve: 382(M++Na);

1H NMR (400MHz, DMSO-d6:
8.44 (d, J=5.6
Hz, 1H), 7.64-7.66 (m, 2H), 7.08-7.10 (m, 3H), 4.60-4.86
(dd, J=13.6, 2H), 4.25 (t, J=6.4 Hz, 2H), 3.64 (t, J=6.4Hz,
2H), 3.40 (s, 3H), 2.31 (s, 3H), 2.13 (qn, J=6.4, 2H).

13CNMR (100 MHz, DMDO-d6) 162.67, 154.68, 150.35,
147.69, 121.40, 119.79, 117.38, 110.49, 106.27, 68.31,
65.09, 57.95, 36.25, 28.68, 10.36.
 .......................................................

 1H NMR (CDCl3
+DMSO) of Rabeprazole sodium (1): δ 2.1 (m, 2H –CH2-), 2.2 (s, 3H, -
CH3), 3.3 (s, 3H, -OCH3), 3.6 (t, 2H, -OCH2-), 4.1 (t, 2H,-CH2-OCH3), 4.5 (d, Ha, -CH2-
pyridine), 4.7 (d, Hb, -CH2-pyridine), 6.6 (d, 1H, 1H-pyridine), 7.1-7.6 (m, 4H, Ar-H),
8.2 (d, 1H, pyridine). http://rasayanjournal.co.in/vol-1/issue-1/21.pdf
.....



 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf  ...........GET IR, NMR GRAPHS FOR RABEPRAZOLE SODIUM HERE

 .....................................................................





......................................................................
SPECTRAL DATA FOR RABEPRAZOLE (WITHOUT SODIUM)

IR (KBr, cm-1) 3064 (Ar-H), 2898(Ali-H), 1581 (aromatic
C=C), 1300 (C-N), 1095 (C-O arylalkylether),1060 (S-O,
sulphoxide), 753 (Ar-H bending);

MS( ESI)+ve: 360(M++1);

1H NMR (400MHz, DMSO-d6: 12.98 (brs, NH),8.28 (d, J=5.6 Hz, 1H), 7.69-7.61 (m, 3H), 6.70 (d, 2H),4.69-4.82 (dd, J=13.6, 2H), 4.05 (t, J=6.4 Hz, 2H), 3.51 (t,J=6.4Hz, 2H), 3.38 (s, 3H), 2.13 (s, 3H), 2.05 (qn, J=6.4,2H).

13C NMR (100 MHz, DMDO-d6)
163.68, 153.14,149.12, 148.22, 122.87, 119.74, 117.40, 110.50, 106.19,
68.74, 65.12, 58.75, 36.27, 29.21, 11.05.



 READ
http://jocpr.com/vol4-iss1-2012/JCPR-2012-4-1-130-139.pdf
 http://www.asianpharmaonline.org/ajpr/3_ajpr_1_1_2011.pdf
 http://www.ncbi.nlm.nih.gov/pubmed/17945453
 http://www.jcbsc.org/journal/Paper/Vol_2_I_3_2012/A14.pdf
 http://rasayanjournal.co.in/vol-1/issue-1/21.pdf




LATUR, MAHARASHTRA, INDIA

http://en.wikipedia.org/wiki/Latur

Latur लातूर Lattalur, Ratnapur
City
Latur Location in Maharashtra, India
Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E
Country	India
State	Maharashtra
Region	Aurangabad Division
District	Latur
Settled	Possibly 7th century AD
Government
• Body	Latur Municipal Corporation
• Mayor	Akhtar Shaikh
Area[1]
• Total	117.78 km2(45.48 sq mi)
Area rank	89
Elevation	515 m (1,690 ft)
Population (2011)
• Total	382,754
• Rank	89th
• Density	3,200/km2(8,400/sq mi)
Demonym	Laturkar
Languages
• Official	Marathi
Time zone	IST (UTC+5:30)
PIN	413 512 413 531
Telephone code	91-2382
Vehicle registration	MH-24
Sex ratio	923.54 ♀/1000 ♂
Literacy	89.67
Distance from Mumbai	497 kilometres (309 mi) E (land)
Distance fromHyderabad	337 kilometres (209 mi) NW (land)
Distance fromAurangabad, Maharashtra	294 kilometres (183 mi) SE (land)
Climate	BSh (Köppen)
Precipitation	666 millimetres (26.2 in)
Avg. summer temperature	41 °C (106 °F)
Avg. winter temperature	13 °C (55 °F)
http://www.citypopulation.de/world/Agglomerations.html

his Is The Famous 'Ganj-Golai' As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers ...




लातूर जिल्हयातील चित्र संग्रह

1. Colleges and Universities
   View 2+ more

   

   Rajarshi Shahu College...

   

   Government Medical College...

   

   M. S. Bidve Engineering College...

   

   Mahatma Basweshwar College L...

   

   Dayanand Pharmacy College L...

LATUR AIRPORT

LATUR AIRPORT













2012 Navratri Mahotsav in Latur





SOS Children's Village Latur











Latur, India: Carnival Resort









Ausa Near Latur







Chakur near Latur



Vilasrao Deshmukh's ancestral home at Babhalgaon village in Latur. Machindra Amle

















UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas ...







The city of Latur is located in India's welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the 

Trazodone Hydrochloride

Synthesis of Trazodone Hydrochloride

The Trazodone Hydrochloride drug molecule (Compound T), was prepared using the process
described in Scheme 1, which involves simple condensation of 1-(3-chlorophenyl)-4-(3-
chloropropyl) piperazine and 1, 2, 4-triazolo [4, 3-a] pyridine-3- (2H)-one intermediates [8].
In first part of the process bis-(2-chloroethylamine) hydrochloride (Compound P) is prepared
by chlorination of diethanolamine with thionyl chloride in xylene, which is then condensed
with 3-chloro aniline to get 1-(3-chlorophenyl)-piperazine hydrochloride intermediate
(Compound Q). This is reacted with 3-bromo-3-chloropropane in alkaline aqueous acetone
(50 %) gave various 1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine intermediate
(Compound R). In second part of the process, 1-(3-chlorophenyl)-4-(3-chloropropyl)
piperazine is condensed with sodium salt of 1, 2, 4-triazolo [4, 3-a] pyridine-3- (2H)-one
(Compound S) prepared in a single step process by reaction of 2-chloropyridine and
semicarbazide hydrochloride in 2-ethoxyethanol afforded lead compound (Compound T),
isolated as hydrochloride salt. The yields of 1-(3-chlorophenyl)-piperazine hydrochloride (Q),
1-(3-chlorophenyl)-4-(3-chloropropyl) piperazine (R) and of Trazodone Hydrochloride (T)
reported in the literature and observed in the lab are 84-85%, 72-73%, 84-85% respectively.
The intermediate 1, 2, 4-triazolo [4, 3-a] pyridine-3- (2H)-one (S) is obtained in >90 % yield
and in desired purity. But the process involves long reaction hours (>12) and elevated
temperature (145-150 0C).

http://jocpr.com/vol2-iss5-2010/JCPR-2010-2-5-506-517.pdf

IR

3000 (aromatic C-H stretching),
2954 (aliphatic C-H stretching),
1704 (C=O stretching),
1650 (C=N stretching),
1600 (aromaticC=C stretching),
1350 (C-N stretching),
750 (C-Cl stretching)



NMR
ð 2.16-2.12 ppm (t, 2H, -CH2),
2.64-2.60 (t, 2H, -N CH2),
2.73 (s,4H, -CH2-N-CH2),
3.09 (s, 4H, CH2-N-CH2),
4.12-4.07 (t, 2H,-CH2-N),
6.51-6.46 (m,1H, -ArH),
7.02-6.93 (m, 2H,-ArH),
7.09-7.08 (d, 2H, -ArH),
7.26-7.17 (m, 1H, -ArH),
7.34-7.31 (d, 1H, -ArH),
7.76-7.74 (d, 1H, -ArH)

SEE........http://pubs.rsc.org/en/content/articlelanding/2010/ay/c0ay00290a/unauth#!divAbstract

A robust method for in vitro metabolite generation and facile sample preparation on analyticalHPLC was established for rapid structure determination of microgram-level drug metabolites by using high-field NMR equipped with a cryoprobe. A single 1–5 mL incubation of drug candidate (10–30 μM) in microsomes, hepatocytes, or recombinant drug-metabolising enzymes, typicallycytochrome P450s and UDP-glucuronosyltransferases, was used for metabolite formation. Following precipitation of proteins and solvent removal, metabolite mixtures were chromatographed with 5–10 injections onto an HPLC-MS system. Metabolites were collected into a 96-well plate, dried, and reconstituted in deuterated NMR solvents. NMR spectra of isolated metabolites were acquired on a 500 MHz spectrometer equipped with a 5 mm cryogenic probe. The methodology has been successfully employed as an extension of HPLC-MS/MS-based metabolite identification and applied frequently to 0.5–10 μg quantities of metabolite. Most structure determinations were achieved rapidly by 1D ¹H NMR with satisfactory signal-to-noise ratios, whereas some required 2D NMR data analysis. This report describes the method development and metabolite structure determination using the model compoundtrazodone. In addition to trazodone, a large number of examples from our laboratories have proven that the microgram-level NMR method avoids time-consuming preparative-scalemetabolite generation and purification and circumvents technical complications associated with online LC-NMR. Most importantly, the turnaround time of metabolite structure determination for metabolically unstable compounds using the present methodology is more in sync with the cycle time during which medicinal chemists modify metabolic softspots while performing other iterative lead optimisation activities, demonstrating a real impact on the drug-discovery process.

NMR PREDICTIONS

H-NMR spectral analysis

CAS NO. 25332-39-2, Trazodone hydrochloride H-NMR spectral analysis

C-NMR spectral analysis

CAS NO. 25332-39-2, Trazodone hydrochloride C-NMR spectral analysis

//////////////////////////////



 amcrasto@gmail.com

http://newdrugapprovals.org/

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO

LATUR, MAHARASHTRA, INDIA

http://en.wikipedia.org/wiki/Latur

Latur लातूर Lattalur, Ratnapur
City
Latur Location in Maharashtra, India
Coordinates: 18.40°N 76.56°ECoordinates: 18.40°N 76.56°E
Country	India
State	Maharashtra
Region	Aurangabad Division
District	Latur
Settled	Possibly 7th century AD
Government
• Body	Latur Municipal Corporation
• Mayor	Akhtar Shaikh
Area[1]
• Total	117.78 km2(45.48 sq mi)
Area rank	89
Elevation	515 m (1,690 ft)
Population (2011)
• Total	382,754
• Rank	89th
• Density	3,200/km2(8,400/sq mi)
Demonym	Laturkar
Languages
• Official	Marathi
Time zone	IST (UTC+5:30)
PIN	413 512 413 531
Telephone code	91-2382
Vehicle registration	MH-24
Sex ratio	923.54 ♀/1000 ♂
Literacy	89.67
Distance from Mumbai	497 kilometres (309 mi) E (land)
Distance fromHyderabad	337 kilometres (209 mi) NW (land)
Distance fromAurangabad, Maharashtra	294 kilometres (183 mi) SE (land)
Climate	BSh (Köppen)
Precipitation	666 millimetres (26.2 in)
Avg. summer temperature	41 °C (106 °F)
Avg. winter temperature	13 °C (55 °F)
http://www.citypopulation.de/world/Agglomerations.html

his Is The Famous 'Ganj-Golai' As The Central Place Of The Latur City. There Are 16 Roads Connecting To This Place And Seperate Markets i.e. Jewellers ...




लातूर जिल्हयातील चित्र संग्रह

1. Colleges and Universities
   View 2+ more

   

   Rajarshi Shahu College...

    

   

   Government Medical College...

    

   

   M. S. Bidve Engineering College...

    

   

   Mahatma Basweshwar College L...

    

   

   Dayanand Pharmacy College L...

LATUR AIRPORT

LATUR AIRPORT













2012 Navratri Mahotsav in Latur





SOS Children's Village Latur











Latur, India: Carnival Resort









Ausa Near Latur







Chakur near Latur



Vilasrao Deshmukh's ancestral home at Babhalgaon village in Latur. Machindra Amle

















UDGIR: Udgir is one of the most important towns of Latur district. Udgir has a great historical significance. It has witnessed the war between the Marathas ...







The city of Latur is located in India's welathiest state, Maharashtra. Together with many of the surrounding villages, Latur was all but destroyed in the