MIDOSTAURIN
https://www.google.co.in/patents/US5093330
EXAMPLE 18 N-benzoyl-staurosporine
0.035 ml (0.3 mmol) of benzoyl chloride is added at room temperature to a solution of 116.5 mg (0.25 mmol) of staurosporine and 0.065 ml (0.38 mmol) of N,N-diisopropylethylamine in 2 ml of chloroform and the whole is stirred for 10 minutes. The reaction mixture is diluted with chloroform, washed with sodium bicarbonate solution, dried over magnesium sulphate and concentrated by evaporation. The crude product is chromatographed on silica gel (eluant:methylene chloride/ethanol 30:1); m.p. 235
SEE FULL REPORT ON
http://www.allfordrugs.com/2014/01/14/midostaurin-with-potential-antiangiogenic-and-antineoplastic-activities/
