Methyl 3-(4-Isobutyl-2-methyl-1-oxo-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-7-yl)benzoate

Methyl 3-(4-Isobutyl-2-methyl-1-oxo-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-7-yl)benzoate (8)

crude solid which after flash chromatography purification using hexane–ethyl acetate (1:1) gave 8 as a buff solid (0.202 g, 71%). ¹H NMR (CDCl₃, 400 MHz) δ 9.84 (br s, 1H), 8.14 (s, 1H), 8.40 (d, J = 8.0 Hz, 1H), 8.34 (s, 1H), 7.95 (d, J = 7.8 Hz, 1H) 7.48 (t, J = 7.6 Hz, 1H), 7.15 (d, J = 2.7 Hz, 1H), 3.90 (s, 3H), 3.74 (s, 3H), 2.60 (d, J = 7.4 Hz, 2H), 2.23–2.12 (septet, 1H), 1.01 (d, J = 6.6 Hz, 6H) ppm; ¹³C NMR (CDCl₃, 100 MHz) δ 166.7, 158.6, 144.6, 133.7, 130.8, 130.8, 129.9, 128.8, 128.3, 121.7, 113.2, 111.2, 60.4, 52.2, 41.9, 38.1, 28.0, 22.7 ppm; LRMS (ES-TOF) m/z: [M – H] Calc’d for C₁₉H₂₁N₃O₃: 339.38, Found: 338.40.

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