DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label NORWAY. Show all posts
Showing posts with label NORWAY. Show all posts

Monday 18 May 2015

Benzyl glycidyl ether

\

Benzyl glycidyl ether



Chiral HPLC
Column: Chiralcel OD-H (0.46 x 25 cm)
Detection: UV (254 nm) (In a few cases 214 nm was used.)
Benzyl Glycidyl Ether Analysis
Eluent: 10% iPrOH:90% Hexanes
Flow rate: 1.0 mL/min
Retention times of the two enantiomers: 8.2 and 9.0 minutes
Typical percentages of the two enantiomers using catalyst synthesized using L-Tartaric acid: 98.7% (8.2 min RT), 1.3% (9.0 min RT)
Typical percentages of the two enantiomers using catalyst synthesized using D-Tartaric acid: 3.5% (8.2 min RT), 96.5% (9.0 min RT)
3-Benzyloxy-1,2-propanediol Analysis
Eluent: 15% iPrOH:85% Hexanes
Flow rate: 0.9 mL/min
Retention times of the two enantiomers: 11.1 and 13.1 minutes
Typical percentages of the two enantiomers using catalyst synthesized using L-Tartaric acid: 84.0% (11.1 min RT), 16.0% (13.1 min RT)
Typical percentages of the two enantiomers using catalyst synthesized using D-Tartaric acid: 2.7% (11.1 min RT), 97.3% (13.1 min RT)
Optical Rotation
Jacobsen reports that the R enantiomer of benzyl glycidyl ether is the major one remaining using the (R,R) catalyst. (This is the catalyst produced using the L-Tartaric acid.) For a sample with >99% ee he reports: []26D +10° (c 5.2, MeOH).
Jacobsen reports that the R enantiomer of the diol is the major one produced using the (R,R) catalyst. (This is the catalyst produced using the L-Tartaric acid.) For a sample with 95% ee he reports: []23D -1.4° (c 3.31, EtOH).




BENZYL GLYCIDYL ETHER NMR spectra analysis, Chemical CAS NO. 2930-05-4 NMR spectral analysis, BENZYL GLYCIDYL ETHER C-NMR spectrum
 oslo, norway

Map of oslo norway .
 

 
 

 





















 


 

 


 
 
 


 

 Frogner-Park-oslo-norway


 Vigelands Park in Oslo, Norway

 
 

 
 Paradisbukta (Paradise Bay), Oslo, Norway 


 
 Norwegian Folk Museum, Oslo, Norway



Vigeland Park sculptures Oslo Norway

II snapped these mini-Viking vessels tied up on the bay across from the Thor Hyerdahl Museum in Oslo, Norway. I loved their vibrant colors on one of the few ...






 


 Karl Johans Gate Oslo Norway |

 

///////////// 

Wednesday 6 May 2015

ANAGLIPTIN


N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide
CAS No.: 739366-20-2
Synonyms:
  • Anagliptin;
Formula: C19H25N7O2
Exact Mass: 383.20700
Anagliptin chemically known as N-[2-[2-[2(S)-cyanopyrrolidin-l-yl]-2-oxoethylamino]- 2-methylpropyl]-2-methylpyrazolo[l,5-a]pyrimidine-6-carboxamide is represented by the structural formula:
Figure imgf000003_0001
Anagliptin is a dipeptidyl peptidase IV- inhibitor. United States Patent No 7345 1 80- (IJS' 180) discloses anagliptin. N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide NMR spectra analysis, Chemical CAS NO. 739366-20-2 NMR spectral analysis, N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide H-NMR spectrum     N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide NMR spectra analysis, Chemical CAS NO. 739366-20-2 NMR spectral analysis, N-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide C-NMR spectrum Example 5: Synthesis of N-[2-2[2(S)-Cyano pyrrolidin-l-yl]-2-oxoethyIamino]-2- methyIpropyl]-2-methyaIpyrazoIo [1, 5-a] pyrimidine-6-carboxamide (I, anagliptin). 1H NMR (300 MHz, CDC13): δ 1.16 (s, 6H), 2.23(m, 4H), 2.54(s, 3H), 3.25-3.51 (m, 6H), 4.78 (m, 1H), 6.53 (s, 1H), 8.05 (s, 1H), 8.93 (s, 1H), 9.22(s, 1H) HPLC Purity: 99.71%, Chiral purity: 100%

.........WO2014147640A2




 Kato, M.; Oka, M.; Murase, T.; Yoshida, M.; Sakairi, M.; Yamashita, S.; Yasuda, Y.; Yoshikawa, A.; Hayashi, Y.; Makino, M.; Takeda, M.; Mirensha, Y.; Kakigami, T. Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]- 2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorg. Med. Chem. 2011, 19, 7221–7227. http://www.sciencedirect.com/science/article/pii/S0968089611007784 Full-size image (4 K)


NORWAY\




Image result for NORWAY


Map of norway

















Norway: Oslo to Bergen by train










ALESUND




Stave church Heddal, Norway






Norway Bergen Tramway







At the top of Preikestolen with view over the Lysefjord, Norway 





Norway - Bergen Cityscape by AgiVega