POMALIDOMIDE
4-amino-2-(2,6-dixopiperidin-3- yl)isoindoline-l,3-dione; 3-(4-amino-l,3-dioxo-l,3-dihydro-isoindol-2-yl)-piperidine- 2,6-dione; 3-(4-amino-l ,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 1 ,3-dioxo-2-(2,6- dioxopiperidin-3-yl)-4-aminoisoindoline; 3-(l,3-dioxo-4-aminoisoindolin-2-yl)- piperidine-2,6-dione;
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SYNTHESIS AT http://newdrugapprovals.org/2013/08/10/oral-anti-cancer-therapy-pomalidomide-now-approved-by-european-commission-as-treatment-for-patients-with-relapsedrefractory-multiple-myeloma-a-rare-form-of-blood-cancer/
1H NMR PREDICTED
CAS NO. 19171-19-8, 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)- H-NMR spectral analysis 
CAS NO. 19171-19-8, 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)- C-NMR spectral analysis BELOW COSY PREDICT
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1H NMR
1H NMR
Celgene Corporation an orgnization of the state New Jersey Patent: US2007/4920 A1, 2007 ; Location in patent: Page/Page column 13 ;
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 11 p. 1625 - 1630
SEE
https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=4F07F02CB8E1F98D58D9768DCABF0811.wapp1nB?docId=WO2012177678&recNum=80&maxRec=440&office=&prevFilter=&sortOption=&queryString=EN_ALL%3Anmr+AND+PA%3Acelgene&tab=PCTDescription
Pomalidomide has the chemical structure:
and is chemically described variously as: 4-amino-2-(2,6-dixopiperidin-3-yl)isoindoline-l,3-dione; 3-(4-amino-l,3-dioxo-l,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione; 3-(4-amino-l ,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 1 ,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-(l,3-dioxo-4-aminoisoindolin-2-yl)-piperidine-2,6-dione; among other chemical names. Pomalidomide and compositions comprising pomalidomide have utility for, inter alia, treatment of certain cancers {e.g., multiple myeloma, myelodyplastic syndrome, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma) and other various diseases and disorders.
In some embodiments, pomalidomide may be enriched with deuterium,
13C, and/or 15N via the following scheme:
wherein the starting materials, reagents, and/or intermediates are isotopcially-enriched.
[0057] In some embodiments, pomalidomide may be enriched with deuterium,
13C, and/or 15N via the following scheme below:
wherein the starting materials, reagents, and/or intermediates are isotopcially-enriched.
[0058] In certain embodiments, the glutarimide portion of pomalidomide may be enriched with deuterium and/or 13C using deuterium- and/or13C- enriched glutamic acid. For example, commercially available deuterated glutamic acid may be reacted with Compound Al to form Compound Bl . Compound Bl may be subsequently transformed into Compound CI in the presence of acetic anhydride. Compound CI may then be transformed into Compound Dl via reaction with urea. Deuterated
pomalidomide may be obtained from Compound Dl via hydrogenation.
C1
hydrogenation
E1
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Phi Phi Island Thailand
Phi Phi Islands - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Phi_Phi_Islands
The Phi Phi Islands (Thai: หมู่เกาะพีพี, Thai pronunciation: [pʰīː pʰīː]) are located in Thailand, between the large island of Phuket and the western Strait of
.
Thailand is a big market these days for travelers from across the globe. The rare exotic beaches, jungles and the ancient civilization and kingdom built around happiness is a place of relaxation and wonder. Phi Phi Islands are one of the most popular daytrips from the famous beach peninsula of Phuket, but they can also be quiet and inviting places to stay as well. The islands see the most foot traffic around noon till 5pm each day when day trip tours pour in from all sides. During this time the tiny shops, little travel agencies and restaurants of all kinds will be bustling with business. Its not too inconvenient for the island dweller, because one can just as easily avoid the rush by enjoying a nap or wandering out to one of the back beaches where the tourist boats don’t pull up. For those who do enjoy crowds and parties there is a lot going on during the daytime rush too. The island goes back and forth between a vibrant party scene and a quiet tropical isle. 
The hotels are mostly concentrated on the main island of the Phi Phi chain which is called Ko Phi Phi Don Island. All have in common their great location, not one of them is more than two minutes walking from the island beaches. Also one won’t find the massive resort style buildings here that exist in Phuket. Most hotels have a smaller campus with bungalows and rooms never totaling more than 100. This doesn’t mean infrastructure is lacking. There are restaurants, pools, private balconies, coffee shops, gift shops and gardens. Outrigger, Arayaburi, Holiday Inn, Zeavola and Phi Phi beach resort are among the best spots. 
Getting to the island is done by ferry or speedboat. The general access points are from Rassada Pier in Phuket or the pier just outside Krabi town. The prices range from 350-1000 baht depending on the ferry chosen and the time of year. It is a good policy only to buy the tickets you absolutely need, don’t get talked into any deals or combo packages and know that you can buy the same tickets on the dock, in tourist offices and in stores, so shop around and you can find out who will give you the best price. Speedboats are generally much higher in cost, but can be worth it if you are looking to avoid crowds and get to the island as soon as possible. 
The hotels are mostly concentrated on the main island of the Phi Phi chain which is called Ko Phi Phi Don Island. All have in common their great location, not one of them is more than two minutes walking from the island beaches. Also one won’t find the massive resort style buildings here that exist in Phuket. Most hotels have a smaller campus with bungalows and rooms never totaling more than 100. This doesn’t mean infrastructure is lacking. There are restaurants, pools, private balconies, coffee shops, gift shops and gardens. Outrigger, Arayaburi, Holiday Inn, Zeavola and Phi Phi beach resort are among the best spots. Getting to the island is done by ferry or speedboat. The general access points are from Rassada Pier in Phuket or the pier just outside Krabi town. The prices range from 350-1000 baht depending on the ferry chosen and the time of year. It is a good policy only to buy the tickets you absolutely need, don’t get talked into any deals or combo packages and know that you can buy the same tickets on the dock, in tourist offices and in stores, so shop around and you can find out who will give you the best price. Speedboats are generally much higher in cost, but can be worth it if you are looking to avoid crowds and get to the island as soon as possible. 
We are a group of avid and discerning travelers enjoying real life trips, quests and adventures. This is the place to come for everything one needs to know before traveling. Our website delivers a vast range of practical information related to traveling including travel tips, suggested itineraries and overall, practical travel knowledge.
Cheap great deal Phi Phi Hill Resort on Phi Phi Don 2011
Phi Phi Hill Resort on Phi Phi Don 2011 Sorry been away..... dealing with life 'n stuff!! It's high season again and Phi Phi Hill Resort has just opened up for the next 6 months. Phi Phi Hill Resort closes every year around May as the owner head back to Krabi, catch up with friends and family and generally take it easy. High season comes round quick enough and Phi Phi Hill Resort is busy for most of this time. If you are looking for a quiet resort away from the main village, this could be the place for you. If you are wanting to be close to a stunning beach with coral, again Phi Phi Hill resort has that and if you want some of the best views from Phi Phi Don over towards the Tonsai Cliffs or Phi Phi Ley, this place ticks all the boxes. Check it out here; Phi Phi Hill Resort. Prices are from 750 THb a night for 2 people sharing but this will be their most basic room without aircon. However Phi Phi Hill Resort is perched on the top of the Long Beach Headland so there are continual breezes. You can see the Phi Phi Hill Resort prices here.Koh Phangan Full Moon Party Dates
Koh Phangan Full Moon Party Dates
As with many types of traveller, everybody seems to want to know the dates of the next Koh Phangan Full Moon Party. It's almost seems a chant, a rhythmical demand for information about the next party that runs through the conversations every few weeks. The Koh Phangan Full Moon Party holds a strong and focal point for many people who are here to visit Thailand but want to be where it's at. And why not, this party is the biggest in Thailand, Biggest in South East Asia and one of the biggest in the world. A blast, awesome, the best, unmissable, these are just a few of the superlatives to describe it.
Koh Phangan Full Moon Party Dates 2012 see below
As you get down to the half a kilometer wide beach you realize you have stumbled on one of the best settings for a full moon party. The moon rising and setting in front of you, 29 degrees warm sea, a flat line horizon and thousands and thousands of party people...the drums the music the vibe... party paradise.
Through out the season on Phi Phi Island there is an exodus to Koh Phangan Full Moon Party a few days before every Full Moon Party date. All the travel businesses near Phi Phi Don Pier are busy selling the boat- bus- boat- bus joint tickets.
The need for accommodation is also another key aspect of organizing your stay. Don't forget that most places insist that if you book ahead, and this is definitely recommended, you must book a 5 night stay which is not very accommodating. If you arrive there without accommodation you will probably find a place to stay but it might be far from Haad Rin beach (the party beach), badly expensive and of poor quality.... think about it...,. the best places will be booked up ahead. So check out your accommodation before you arrive. You can try places like Siam UK Travel and Tours on Phi Phi Island see them on facebook here. You can also try a great accommodation booking website like hotel-travel-phangan.com
Koh Phangan Full Moon Party Dates 2012Cheap food on Phi Phi Island
Cheap Hotel food on Phi Phi Don
http://cheaphotellondonhotels.blogspot.in/2013/03/cheap-food-on-phi-phi-island.html Most hotels, resorts or guesthouses will offer an international menu at least at breakfast where eggs are ubiquitous form of early morning food. Where the menus get interesting is with the Thai lunches, Chinese noodles and the full blown curries. Inexpensive or cheap food is a matter of the wallet but I would always go for the freshly caught fish as not only is it fresh that morning it will be way more than 70% cheaper than you'd pay or the western capitals. Noodles, noodle soup are good value and variations of fried rice can be sensational. More here on Dining on Phi Phi Island
Cheap Market food on Phi Phi Don
Phi Phi Island market is near the pier on Phi Don Island.Just behind the main street as you walk into to the village there is a thriving market bazaar, selling the entire gamut of fish, meat and vegetables that are common in all Thai cooking. Along side this are the local curry houses where you can find all the local southern favourites from Geng Som to Geng Pla Kem, salty fish and bar b q snapper. My favourites are the fresh seafood curries and as long as you can handle the spices, the fish heads and bones are an amazing culinary experience worthy of more acclaim.
Wholesale prices for food on Phi Phi Island
Phi Phi Don gets it's food from Phuket and Krabi by boat. This is itself explains why food is more expensive as it needs to be handled on and off the boats and the cost of the ferries makes it more expensive.The market is the place to check out prices but haggling is difficult. If you interested in bulk purchases it is better to do your shopping at the talad (market) in Phuket and Krabi.
Cheap Accommodation Near the Market.
Ivory Phi Phi is right on the market itself. Hussin House is very simple and just off the main market near Moskito Diving. Phi Phi Guesthouse Marine House is next door to Hussin House.
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