ORGANIC SPECTROSCOPY INTERNATIONAL: Petriellin A

DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Showing posts with label Petriellin A. Show all posts

Sunday, 21 December 2014

Solution structures by NMR of a novel antifungal drug: Petriellin A

Petriellin A is a novel cyclic depsipeptide antifungal compound consisting of nine L-configured residues, one D-phenyllactic acid (PhLac) and three unknown chiral centres: two N-methyl-threonines (MeThr1 & MeThr2) and one N-methyl-isoleucine (MeIle). NMR experiments including 2D ROESY, NOESY along with structural and energy calculations predicted that the unknown chiral centres were all L-configured, which was later verified chemically. Simulated annealing, dynamics calculations and minimisation processes showed Petriellin A to have a folded “C-shaped” structure.

Org. Biomol. Chem., 2006,4, 3802-3807

DOI: 10.1039/B608434F http://pubs.rsc.org/en/content/articlelanding/2006/ob/b608434f#!divAbstract

Me

DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai), INDIA, worlddrugtracker, 29Yrs Exp. in the field of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational content...........P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent. सुकून उतना ही देना प्रभू, जितने से जिंदगी चल जाये। औकात बस इतनी देना,कि औरों का भला हो जाये।

ORGANIC SPECTROSCOPY INTERNATIONAL

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Sunday, 21 December 2014

Solution structures by NMR of a novel antifungal drug: Petriellin A

Organic Chemistry Select

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