DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label RANBEZOLID. Show all posts
Showing posts with label RANBEZOLID. Show all posts

Wednesday 2 April 2014

Ranbezolid from Ranbaxy as an oxazolidinone antibacterial

Ranbezolid structure.svg

Ranbezolid

392659-39-1 hydrochloride
392659-38-0 (free base)
N-{[(5S)-3-(3-Fluoro-4-{4-[(5-nitro-2-furyl)methyl]-1-piperazinyl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide
(S)-N-[[3-fluoro-4-[N-1[4-{2-furyl-(5-nitro)methyl}]piperazinyl]-phenyl]-2-oxo-5-oxazolidinyl]-methyl]acetamide

  • Mp: 207–209 °C.
  •  1H NMR (DMSO, 300 MHz):  
    δ 8.30 (t, 1H, –NHCO–), 
    7.75 (d, J = 3.3 Hz, 1H, furyl–H), 
    7.52 (dd, 1H, phenyl–H), 
    7.3–7.0 (m, 3H, phenyl–H, furyl–H), 
    4.70 (m, 1H, oxazolidinone ring C5H), 
    4.63 (s, 2H), 
    4.08 (t, J = 8.8 Hz, 1H, –CH2–), 
    3.73 (t, J = 7.5 Hz, 1H), 
    3.43 (br m, piperazine–H merged with H2O in DMSO), 
    .83 (s, 3H, –COCH3).
  • HPLC purity: 98%. 
    Anal. Calcd for C21H25ClN5O6·0.5H2O: C, 50.76; H, 5.48; N, 14.09. Anal. Found: C, 50.83; H, 5.17; N, 13.83.