Catal. Sci. Technol., 2016, Advance Article
DOI: 10.1039/C6CY00855K, Communication
Nicholas J. Weise, Syed T. Ahmed, Fabio Parmeggiani, Elina Siirola, Ahir Pushpanath, Ursula Schell, Nicholas J. Turner
An industrial-scale method employing a phenylalanine ammonia lyase enzyme
Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source
aManchester Institute of Biotechnology & School of Chemistry, University of Manchester, 131 Princess Street, Manchester, UK
E-mail: nicholas.turner@manchester.ac.uk
bJohnson Matthey Catalysts and Chiral Technologies, 28 Cambridge Science Park, Milton Road, Cambridge, UK
Catal. Sci. Technol., 2016, Advance Article
DOI: 10.1039/C6CY00855K
SEE
An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L
−1 d
−1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.
///////Intensified, biocatalytic production, enantiomerically pure, halophenylalanines, acrylic acids, ammonium carbamate, ammonia source
Mnemba, Indian Ocean, Zanzibar,
Tanzania
.
Mnemba Island
Island in Tanzania
Mnemba
Island is a single small island located about 3 km off the northeast
coast of Unguja, the largest island of the Zanzibar Archipelago,
Tanzania, opposite Muyuni Beach.
Wikipedia
Within minutes, we were whisked away to Zanibar’s private gem and warmly
welcomed by the GM, our butler, and a few other members of their team
with cool towels and cocktails. I was hesitant to let my shoes go, but
it was the best thing ever! This is truly a barefoot paradise. Mike, the
GM showed us around & finally to our banda. (the individual rooms
are called bandas) On our first trip during August we stayed in banda 11
on the furthest point of the island with the most magnificent sunrise
view. This time, during January we stayed in banda 4 which was wonderful
for that time of year as it is quite windy.
The banda takes some getting used to as it has a indoor-outdoor feel,
but is private. Each banda is very secluded and don’t worry, you won’t
be caught walking around naked, if you choose to. The only time our
butler would visit (without us asking for his assistance) is to bring us
coffee in the morning at a desired time, which we would give him the
night before. We had Rajab and Christopher as our butlers, both made us
feel at home.
Almost everything in the room is natural and blends in perfectly with
the surroundings. There is no television or telephone available – but
there is Wi-Fi. I don’t need to say much about the bandas, its perfect
and the pictures speak for themselves.
The resort doesn’t have a gym, but you are provided with a gym in a bag.
Honestly speaking, who needs that when you’re on a private island? A
therapist who is also a yoga master is on hand to offer you treatments
in the comfort of your banda.
Breakfast and Lunch is served at the dining area – whenever you wish to
eat, with a different menu each day. The chef is very flexible, if there
is something you would like to eat or change on their menu, they are
ready to oblige.
Let’s talk food – absolutely DELICIOUS to say the least. Chefs Ishan and
Jaco come out each morning to give you the run down of the menu for the
day and that’s when you have an opportunity to alter anything you wish
to. The menu is predominantly seafood, and you cannot get anything
fresher! The best fish I’ve eaten, was at Mnemba.
Each evening at sunset, sun chairs are set outside the Banda facing the
sunset and your butler brings you a cocktail or drink of your choice.
Absolute bliss!
Dinner is usually on the beach – but if the timing of your stay is good,
you will get to experience a beach barbeque (Braai). The pre dinner
drinks on the beach, lit up by candles and lamps is so inviting! You
will also get to experience the Calamari Brothers, a singing duo – Mike
the GM and Jaco, the head chef. The two came together by chance and
ended up getting a name!
Sitting by the beach, listening to music with drink in hand under
moonlight in good company is just perfect. Drinks usually start in the
bar from about 7pm and dinner is served at 8. This is when you get to
meet other guests and the hosts (Members of their team), are always
there to engage you. There are only 12 bandas, so there will be a
maximum of 24 guests – most of the time we felt like we were on our very
own island.
It is by far one of the most romantic places I have ever visited. There
aren’t too many activities on offer – but you can snorkel, dive and swim
with the dolphins and it’s all included in the rate. I went on some
amazing snorkeling expeditions with Matt. We would go out on our own and
explore. Mnemba has some of the most beautiful, untouched reefs I have
ever seen. My husband completed his open water dive course with Marie
and he could not have had a better teacher. The island also has its own
house reef, so you can swim out and snorkel on your own.
Mnemba is small – you can walk around it in about 25min and I loved
taking daily walks exploring on my own. On one side of the island,
during low tide, the sea would recede up to 200m! The natural beauty of
this island is unmatched.
As you walk around you may notice signboards in the sand with dates on
it. One of And Beyond Safari’s priorities is conservation and Mnemba is
one of only two protected nesting sites in Zanzibar for the endangered
green turtle. If you are lucky enough, you will witness the hatching
process and their mini voyage to the ocean. It was such a beautiful
experience, the turtles can barely see, but can sense the sea. It’s
incredible how they gravitate toward the ocean! It’s best not touch them
if you are not wearing gloves as our bacteria can cause them illnesses.
We did meet a little guy with a leg that wasn’t fully formed, but that
didn’t stop him, he took longer than everyone else, but he made it!
As you explore the island you will also meet little deer-like animals,
the suni and ader dyker, both species of antelope. Being some of the
rarest in Africa, they are protected on the island and allowed to breed.
I was hoping to catch sight of the coconut crab but I don’t think he
wanted to see me.
The island seemed to have a micro climate. Mnemba had clear skies
everyday, while the main island of Zanzibar, just across from us, would
be cloudy and rainy, it was very strange but very special!
I can say so much more, but it would never do justice. Hopefully my
pictures show you the true magic of this island. I can’t wait to return!
So long Mnemba, till we meet again.
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