DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label carbonylative Suzuki-Miyaura cross-coupling. Show all posts
Showing posts with label carbonylative Suzuki-Miyaura cross-coupling. Show all posts

Wednesday 31 August 2016

KCC-1 supported palladium nanoparticles as an efficient and sustainable nanocatalyst for carbonylative Suzuki-Miyaura cross-coupling

KCC-1 supported palladium nanoparticles as an efficient and sustainable nanocatalyst for carbonylative Suzuki-Miyaura cross-coupling

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC02012G, Paper
Prashant Gautam, Mahak Dhiman, Vivek Polshettiwar, Bhalchandra M. Bhanage
This work reports a cost-effective and sustainable protocol for the carbonylative Suzuki-Miyaura cross-coupling reaction catalyzed by palladium nanoparticles (Pd NPs) supported on fibrous nanosilica (KCC-1) with very high turnover number.
This work reports a cost-effective and sustainable protocol for the carbonylative Suzuki–Miyaura cross-coupling reaction catalyzed by palladium nanoparticles (Pd NPs) supported on fibrous nanosilica (KCC-1). Under mild reaction conditions, the KCC-1-PEI/Pd catalytic system showed a turnover number (TON) 28-times and a turnover frequency (TOF) 51-times higher than the best supported Pd catalyst reported in the literature for the carbonylative cross-coupling between 4-iodoanisole and phenylboronic acid, as a test reaction. Also, the catalyst could be recycled up to ten times with a marginal loss in activity after the eighth cycle. The high activity of the catalyst can be attributed to the fibrous nature of the KCC-1 support and PEI functionalization provided the enhanced stability.
(4-methoxyphenyl)(phenyl)methanone (3b) 59.3 mg, yield 56%
1H NMR (500 MHz, CDCl3): δ 7.86 (d, J = 8.6 Hz, 2H), 7.78 (d, J = 7.6 Hz, 2H), 7.59 (t, J = 7.4 Hz, 1H), 7.50 (t, J = 7.6 Hz, 2H), 6.99 (d, J = 8.6 Hz, 2H), 3.92 (s, 3H).
13C{1H}NMR (125 MHz, CDCl3): δ 195.4, 163.1, 138.2, 132.4, 131.8, 130.0, 129.6, 128.1, 113.4, 55.4.
GCMS (EI, 70 eV): m/z (%): 212 (40), 135 (100), 105 (14), 77 (36).






KCC-1 supported palladium nanoparticles as an efficient and sustainable nanocatalyst for carbonylative Suzuki–Miyaura cross-coupling

*Corresponding authors
aDepartment of Chemistry, Institute of Chemical Technology, N.P. Marg, Matunga-400019, Mumbai, India
E-mail: bm.bhanage@ictmumbai.edu.in,bm.bhanage@gmail.com
bNanocatalysis Laboratories (NanoCat), Department of Chemical Sciences, Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Colaba, Mumbai, India
E-mail: vivekpol@tifr.res.in
Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC02012G
str1


Image result for Bhalchandra M. Bhanage
\\\\\\\\\\KCC-1 supported,  palladium nanoparticles, sustainable nanocatalyst, carbonylative Suzuki-Miyaura cross-coupling, Prashant Gautam, Mahak Dhiman, Vivek Polshettiwar, Bhalchandra M. Bhanage