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Showing posts with label iran. Show all posts
Showing posts with label iran. Show all posts

Friday, 1 July 2016

BISOPROLOL FUMARATE






















 Fig. 5 ( a ) 13 C solution-state NMR spectrum of bisoprolol in D 2 O at 25 ° C, 13 C CPMAS NMR spectra of ( b ) crystalline and ( c ) quench-cooled (amor-  










https://www.academia.edu/4724422/Asymmetric_synthesis_and_preliminary_evaluation_of_R_-_and_S_-_11C_bisoprolol_a_putative_%CE%B2_1-selective_adrenoceptor_radioligand


/////////////////////http://shodhganga.inflibnet.ac.in/bitstream/10603/27294/8/08_chapter%203.pdf



 MOM WILL TEACH YOU NMR


Yadz, Iran

Map of Yazd Iran
Yazd
City in Iran
Yazd is the capital of Yazd Province, Iran. The city is located 270 km southeast of Esfahan. At the 2011 census, the population was 1,074,428 in 270٬575 families. Wikipedia


 

 

 

 


History

Yazd in the past, History of YazdYazd has a history of over 5,000 years, dating back to the time of the Median empire, when it was known as "Ysatis" (or "Issatis"). The present city name, however, is derived from Yazdegerd I, a Sassanid ruler. The city was definitely a Zoroastrian centre during Sassanid times. After the Arab Islamic conquest of Persia, many Zoroastrians migrated to Yazd from neighbouring provinces. By paying a levy, Yazd was allowed to remain Zoroastrian even after its conquest, and Islam only gradually became the dominant religion in the city.
Yazd in the past, History of YazdBecause of its remote desert location and the difficulty of access, Yazd remained largely immune to large battles and the destruction and ravages of war. For instance, it was a haven for those fleeing from destruction in other parts of Persia during the Mongol invasion. In 1272 it was visited by Marco Polo, who remarked on the citys fine silk-weaving industry. In the book The Travels of Marco Polo, he described Yazd in the following way:
It is a good and noble city, and has a great amount of trade. They weave there quantities of a certain silk tissue known as Yasdi, which merchants carry into many quarters to dispose of. When you leave this city to travel further, you ride for seven days over great plains, finding harbour to receive you at three places only. There are many fine woods producing dates upon the way, such as one can easily ride through; and in them there is great sport to be had in hunting and hawking, there being partridges and quails and abundance of other game, so that the merchants who pass that way have plenty of diversion. There are also wild asses, handsome creatures. At the end of those seven marches over the plain, you come to a fine kingdom which is called Kerman.
Yazd briefly served as the capital of the Muzaffarid Dynasty in the fourteenth century, and was unsuccessfully besieged in 1350–1351 by the Injuids under Shaikh Abu Ishaq. The Friday (or Congregation) Mosque, arguably the citys greatest architectural landmark, as well as other important buildings, date to this period. During the Qajar dynasty (18th Century AD) it was ruled by the Bakhtiari Khans.
Under the rule of the Safavid (16th century), some people migrated from Yazd and settled in an area that is today on the Iran-Afghanistan border. The settlement, which was named Yazdi, was located in what is now Farah City in the province of the same name in Afghanistan. Even today, people from this area speak with an accent very similar to that of the people of Yazd.
The people of Yazd are known for being peaceful, clever, and hard-working. One of the notable things about Yazd is its family-centred culture. According to official statistics from Irans National Organization for Civil Registration, Yazd is among the three cities with the lowest divorce rates in Iran.

 
 

 
 

 

 Fire Temple in Ardakan, Yazd









 
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Thursday, 12 May 2016

Copper catalysed alkynylation of tertiary amines with CaC2 via sp3 C-H activation


Green Chem., 2016, Advance Article DOI: 10.1039/C6GC00872K, Communication
Siew Ping Teong, Dingyi Yu, Yin Ngai Sum, Yugen Zhang A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through sp3 C-H bond activation and C-C coupling of tertiary amines and calcium carbide has been developed.

Copper catalysed alkynylation of tertiary amines with CaC2 via sp3 C–H activation

Siew Ping Teong,a   Dingyi Yu,a   Yin Ngai Suma and  Yugen Zhang*a  
*Corresponding authors
aInstitute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore E-mail: ygzhang@ibn.a-star.edu.sg
Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC00872K
http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC00872K?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract
A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide has been developed. The reaction proceeds via sp3 C–H bond activation and C–C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C–H reactivity.
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N-methyl-N-(prop-2-yn-1-yl)cyclohexanamine (3a) This compound was prepared according to general procedure and isolated by column chromatography (ethyl acetate/hexane = 1/8) to give the product as a light yellow liquid (139 mg, 92%). 1H NMR (400 MHz, CDCl3) δ 3.42 (d, J = 2.4 Hz, 2H, CH2), 2.39 – 2.31 (m, 1H, CH), 2.35 (s, 3H, CH3), 2.19 (t, J = 2.5 Hz, 1H, C≡CH), 1.92 – 1.90 (m, 2H, CH2), 1.78 – 1.75 (m, 2H, CH2), 1.62 – 1.59 (m, 1H, CH2), 1.31 – 1.08 (m, 5H, CH2); 13C NMR (101 MHz, CDCl3) δ 79.8, 72.6, 60.7, 42.9, 38.5, 29.8, 26.0, 25.5; HRMS (EI) m/z calcd. for C 10 H 17 N 151.1361; found 151.1358
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/////Copper catalysed alkynylation,  tertiary amines,  CaC2,  sp3 C-H activation

Farsi Island, iran

Farsi Island is located in Iran
Farsi Island
Approximate location of Farsi Island















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Tuesday, 10 May 2016

Multibiphenyl A, New biphenyls from Garcinia multiflora.


Figure 2 Selected HMBC (H→C) and 1H-1H correlation spectroscopy (COSY) (–) correlations of 1. 
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Compound 1 was obtained as a pale yellow gum. The molecular formula was determined to be C20H22O6 from the molecular ion peak [M]+ at m/z 358.1408 in the EI-HRMS. The IR spectrum indicated that 1 possesses hydroxy (3422 cm-1), phenyl (2939, 1498 cm-1), and carbonyl (1721 cm-1) functional groups. The 1H and 13C NMR spectra (Table 1) revealed the signals for a 1,2,3,4,5-pentasubstituted benzene ring [dH 6.26 (1H, s, H-6); δC 129.6 (C-1), 119.7 (C-2), 144.9 (C-3), 135.0 (C-4), 147.2 (C-5), 105.9 (C-6)], one p-substituted benzene ring [dH 7.00 (2H, dd, J 8.8, 2.4 Hz, H-8, H-12), 6.74 (2H, dd, J 8.8, 2.4 Hz, H-9, H-11); δC 133.8 (C-7), 131.7 (C-8, C-12), 115.7 (C-9, C-11), 157.1 (C-10)], one acetoxyprenyl group [dH 3.21 (2H, d, J 6.7 Hz, H-1'), 5.44 (1H, d, J6.7 Hz, H-2'), 4.33 (2H, s, H-4'), 1.39 (3H, s, H-5'), and 1.99 (3H, s, H-OAc); δC 26.8 (C-1'), 130.7 (C-2'), 134.6 (C-3'), 71.5 (C-4'), 14.0 (C-5'), 172.9, 20.8 (OAc)], and one methoxy group [dH 3.76 (3H, s, OMe-5); δC 56.5 (OMe)], which implied that compound1 was a biphenyl derivative. This conclusion was confirmed by the heteronuclear multiple bond correlation (HMBC) correlations of H-6 with C-7, and of H-8 and H-12 with C-1 (Figure 2). HMBC correlations of H-1' with C-1, C-2, and C-3, and of H-2' with C-1 suggested the acetoxyprenyl group at C-2. The methoxy group was located at C-5 from the HMBC correlations of δH 3.76 (OMe) with C-5. Considering the signal for quarternary C-3, C-4, C-10 and the molecular formula of 1, three hydroxy groups were located at C-3, C-4, C-10, respectively. Thus, the structure of 1 was determined as shown (Figure 1), and named multibiphenyl A.
Figure 1 New biphenyls from Garcinia multiflora
Multibiphenyl A (1)
Pale yellow gum; [α]D –11.0 (c 0.07, MeOH); UV (MeOH) lmax / nm (log ε) 570 (2.16), 205 (4.71); IR (KBr) n / cm-1 3422, 2939, 1721, 1611, 1589, 1498, 1443, 1357, 1266, 1172, 1102, 1045, 1023, 838; 1H and 13C NMR data (400 and 100 MHz, CD3OD), see Table 1; ESI-MS (positive mode) m/z 381 [M + Na]+; EI-HRMS (M+) calcd.: 358.1416; found: 358.1408 (C20H22O6).

Table 1 1H and 13C NMR data for compounds 1-3 (d in ppm, 1 and 2 in CD3OD, 3 in CDC13, 100 and 400 MHz) 
No.123
δC (m) / ppmδH (m, J , Hz) / ppmδC (m) / ppmδH (m, J , Hz) / ppmδC (m) / ppmδH (m, J , Hz) / ppm
1129.6 s132.4 s132.3 s
2119.7 s114.2 s112.4 s
3144.9 s142.0 s141.5 s
4135.0 s131.9 s132.7 s
5147.2 s149.6 s144.8 s
6105.9 d6.26 (s, 1H )106.6 d6.44 (s, 1H)105.5 d6.43 (s, 1H)
7133.8 s134.6 s132.7 s
8131.7 d7.00 (dd, 1H, J 8.8 Hz, 2.4)131.8 d7.11 (dd, 1H, J 8.4 Hz, 1.9)130.3 d7.16 (d, 1H, J 8.6 Hz)
9115.7 d6.74 (dd, 1H, J 8.8 Hz, 2.4)116.0 d6.82 (dd, 1H, J 8.4 Hz, 1.9)114.8 d6.86 (d, 1H, J 8.6 Hz)
10157.1 s157.7 s155.5 s
11115.7 d6.74 (dd, 1H, J 8.8 Hz, 2.4)116.0 d6.82 (dd, 1H, J 8.4 Hz, 1.9)114.8 d6.86 (d, 1H, J 8.6 Hz)
12131.7 d7.00 (dd, 1H, J 8.8 Hz, 2.4)131.8 d7.11 (dd, 1H, J 8.4 Hz, 1.9)130.3 d7.16 (d, 1H, J 8.6 Hz)
1'26.8 t3.21 (d, 2H, J 6.7 Hz, CH2)124.7 d6.41 (d, 1H, J 10.1 Hz)21.1 t2.59 (t, 2H, J 6.6 Hz, CH2)
2'130.7 d5.44 (t, 1H, J 6.7 Hz)124.4 d5.48 (d, 1H, J 10.1 Hz)33.0 t1.72 (t, 2H, J 6.6 Hz, CH2)
3'134.6 s77.6 s74.7 s
4'71.5 t4.33 (s, 3H, CH3)69.0 t4.27 (d, 1H, J 11.5 Hz, CH2)26.7 q1.39 (s, 3H, CH3)
4.14 (d, 1H, J 11.5 Hz, CH2)
5'14.0 q1.39 (s, 3H, CH3)23.4 q1.47 (s, 3H, CH3)26.7 q1.39 (s, 3H, CH3)
3-OMe56.5 q3.76 (s, 3H, OCH3)56.5 q3.85 (s, 3H, OCH3)56.1 q3.86 (s, 3H, OCH3)
5'- OAc172.9 s172.6 s
20.8 q1.99 (s, 3H, COCH3)20.7 q2.00 (s, 3H, COCH3)

Journal of the Brazilian Chemical Society

On-line version ISSN 1678-4790

J. Braz. Chem. Soc. vol.27 no.1 São Paulo Jan. 2016

http://dx.doi.org/10.5935/0103-5053.20150235

ARTICLES
New Biphenyls from Garcinia multiflora
Xue-Mei Gaoa  b  , Bing-Kun Jia  b  , Yin-Ke Lia  c  , Yan-Qing Yea  , Zhi-Yong Jianga  , Hai-Ying Yanga  , Gang Dua  , Min Zhoua  , Xiao-Xia Pana  , Wen-Xing Liua  , Qiu-Fen Hua  * 
aKey Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Kunming, P. R. China
bJoint Research Centre for International Cross-Border Ethnic Regions Biomass Clean Utilization in Yunnan, Yunnan Minzu University, 650031 Kunming, P. R. China
cCollege of Resource and Environment, Yuxi Normal University, 653100 Yuxi, P. R. China
ABSTRACT
Three new biphenyls were isolated from Garcinia multiflora. The structures of these biphenyls were elucidated by spectroscopic methods, and their rotavirus activity was evaluated.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000100010&lng=en&nrm=iso&tlng=en
Key words: Garcinia multiflora,  biphenyls,  anti-rotavirus activity

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Iranian food
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