DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Showing posts with label isoxazolopyridin-3-amine derivatives. Show all posts
Showing posts with label isoxazolopyridin-3-amine derivatives. Show all posts

Sunday 25 September 2016

A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives








A highly efficient and green method has been developed for the rapid preparation of highly functionalized isoxazolopyridin-3-amine derivatives in excellent yields. This process has a broad substrate scope, is operationally simple, and generally requires no chromatographic purification. In addition, the process is scalable and significantly greener than current alternatives with a PMI of 18 and water as the reaction solvent.



Graphical abstract: A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives


Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives









































Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives











Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives


Image result for A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives



A rapid preparation of highly functionalized isoxazolopyridin-3-amine and other heterocyclic fused aminoisoxazole derivatives


A high-yielding method for the preparation of isoxazolopyridin-3-amine derivatives

Wensheng Yu,*a   Paul G. Bulgerb and   Kevin M. Maloney*b  

*
Corresponding authors
a
Discovery Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, USA
E-mail: wensheng.yu@merck.com
b
Process Chemistry, Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, USA
Green Chem., 2016,18, 4941-4946

DOI: 10.1039/C6GC01125J















http://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC01125J?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract


Wensheng Yu


Wensheng Yu

Associate Principal Scientist at Merck



Image result for Paul G. Bulger merck

Paul G. Bulger was born in London, England, in 1978. He received his undergraduate M.Chem degree in 2000 from the University of Oxford, completing his Part II project under the supervision of Dr. Mark G. Moloney. He remained at Oxford for his graduate studies, obtaining his D. Phil. in chemistry in 2003 for research conducted under the supervision of Professor Sir Jack E. Baldwin. After an enjoyable three-year stint as a postdoctoral researcher in Professor K. C. Nicolaou's group at The Scripps Research Institute, he joined the Process Research Department of Merck & Co., Inc. in the fall of 2006.






pic not available



Kevin Maloney

Sr Research Chemist at Merck Sharp & Dohme


Experience



Sr Research Chemist

Merck
 – Present (9 years)

/////////////
Chopda is a city and a municipal council in Jalgaon district in the state of Maharashtra, India.


Chopda
City in India
Chopda is a city and a municipal council in Jalgaon district in the state of Maharashtra, India. Wikipedia
Map of Chopda India



Image result for Chopda City in Maharashtra, India

Image result for Chopda City in Maharashtra, India




Image result for Chopda City in Maharashtra, India


Image result for Chopda City in Maharashtra, India


Image result for Chopda City in Maharashtra, India

Image result for Chopda City in Maharashtra, India


Image result for Chopda City in Maharashtra, India


Image result for Chopda City in Maharashtra, India


Image result for Chopda City in Maharashtra, India



///////