.Carbon-13 INADEQUATE 2-D spectrum of form II of oxybuprocain hydrochloride
NMR studies of organic polymorphs & solvates
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Department of Chemistry, University of Durham, South Road, Durham, UK
E-mail: r.k.harris@durham.ac.uk
E-mail: r.k.harris@durham.ac.uk
Analyst, 2006,131, 351-373
DOI: 10.1039/B516057J
This review article describes the applications of NMR to the study of polymorphs and related forms (solvates) of organic (especially pharmaceutical) compounds, for which it is of increasing academic and practical importance. The nature of the systems covered is briefly introduced, as are the techniques constituting solid-state NMR. The methodologies involved are then reviewed under a number of different headings, ranging from spectral editing through relaxation times to shielding tensors and NMR crystallography. In each case the relevant applications are described. Whilst most studies concentrate on structural matters, motional effects are not neglected. A special section discusses studies of solvates (especially hydrates), and another reviews quantitative analysis.
