Organic Chemists from Industry and academics to Interact on Spectroscopy Techniques for Organic Compounds ie NMR, MASS, IR, UV Etc. Starters, Learners, advanced, all alike, contains content which is basic or advanced, by Dr Anthony Melvin Crasto, Worlddrugtracker, email me ........... amcrasto@gmail.com, call +91 9323115463 India skype amcrasto64
................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution
Catal. Sci. Technol., 2016, Advance Article
DOI: 10.1039/C6CY00855K, Communication
Nicholas J. Weise, Syed T. Ahmed, Fabio Parmeggiani, Elina Siirola, Ahir Pushpanath, Ursula Schell, Nicholas J. Turner
An industrial-scale method employing a phenylalanine ammonia lyase enzyme
aManchester Institute of Biotechnology & School of Chemistry, University of Manchester, 131 Princess Street, Manchester, UK
E-mail: nicholas.turner@manchester.ac.uk
bJohnson Matthey Catalysts and Chiral Technologies, 28 Cambridge Science Park, Milton Road, Cambridge, UK
An intensified, industrially-relevant strategy for the production of enantiopure halophenylalanines has been developed using the novel combination of a cyanobacterial phenylalanine ammonia lyase (PAL) and ammonium carbamate reaction buffer. The process boasts STYs up to >200 g L−1 d−1, ees ≥ 98% and simplified catalyst/reaction buffer preparation and work up.
///////Intensified, biocatalytic production, enantiomerically pure, halophenylalanines, acrylic acids, ammonium carbamate, ammonia source
Mnemba, Indian Ocean, Zanzibar,
Tanzania
.
Mnemba Island
Island in Tanzania
Mnemba
Island is a single small island located about 3 km off the northeast
coast of Unguja, the largest island of the Zanzibar Archipelago,
Tanzania, opposite Muyuni Beach. Wikipedia
Within minutes, we were whisked away to Zanibar’s private gem and warmly
welcomed by the GM, our butler, and a few other members of their team
with cool towels and cocktails. I was hesitant to let my shoes go, but
it was the best thing ever! This is truly a barefoot paradise. Mike, the
GM showed us around & finally to our banda. (the individual rooms
are called bandas) On our first trip during August we stayed in banda 11
on the furthest point of the island with the most magnificent sunrise
view. This time, during January we stayed in banda 4 which was wonderful
for that time of year as it is quite windy.
The banda takes some getting used to as it has a indoor-outdoor feel,
but is private. Each banda is very secluded and don’t worry, you won’t
be caught walking around naked, if you choose to. The only time our
butler would visit (without us asking for his assistance) is to bring us
coffee in the morning at a desired time, which we would give him the
night before. We had Rajab and Christopher as our butlers, both made us
feel at home.
Almost everything in the room is natural and blends in perfectly with
the surroundings. There is no television or telephone available – but
there is Wi-Fi. I don’t need to say much about the bandas, its perfect
and the pictures speak for themselves.
The resort doesn’t have a gym, but you are provided with a gym in a bag.
Honestly speaking, who needs that when you’re on a private island? A
therapist who is also a yoga master is on hand to offer you treatments
in the comfort of your banda.
Breakfast and Lunch is served at the dining area – whenever you wish to
eat, with a different menu each day. The chef is very flexible, if there
is something you would like to eat or change on their menu, they are
ready to oblige.
Let’s talk food – absolutely DELICIOUS to say the least. Chefs Ishan and
Jaco come out each morning to give you the run down of the menu for the
day and that’s when you have an opportunity to alter anything you wish
to. The menu is predominantly seafood, and you cannot get anything
fresher! The best fish I’ve eaten, was at Mnemba.
Each evening at sunset, sun chairs are set outside the Banda facing the
sunset and your butler brings you a cocktail or drink of your choice.
Absolute bliss!
Dinner is usually on the beach – but if the timing of your stay is good,
you will get to experience a beach barbeque (Braai). The pre dinner
drinks on the beach, lit up by candles and lamps is so inviting! You
will also get to experience the Calamari Brothers, a singing duo – Mike
the GM and Jaco, the head chef. The two came together by chance and
ended up getting a name!
Sitting by the beach, listening to music with drink in hand under
moonlight in good company is just perfect. Drinks usually start in the
bar from about 7pm and dinner is served at 8. This is when you get to
meet other guests and the hosts (Members of their team), are always
there to engage you. There are only 12 bandas, so there will be a
maximum of 24 guests – most of the time we felt like we were on our very
own island.
It is by far one of the most romantic places I have ever visited. There
aren’t too many activities on offer – but you can snorkel, dive and swim
with the dolphins and it’s all included in the rate. I went on some
amazing snorkeling expeditions with Matt. We would go out on our own and
explore. Mnemba has some of the most beautiful, untouched reefs I have
ever seen. My husband completed his open water dive course with Marie
and he could not have had a better teacher. The island also has its own
house reef, so you can swim out and snorkel on your own.
Mnemba is small – you can walk around it in about 25min and I loved
taking daily walks exploring on my own. On one side of the island,
during low tide, the sea would recede up to 200m! The natural beauty of
this island is unmatched.
As you walk around you may notice signboards in the sand with dates on
it. One of And Beyond Safari’s priorities is conservation and Mnemba is
one of only two protected nesting sites in Zanzibar for the endangered
green turtle. If you are lucky enough, you will witness the hatching
process and their mini voyage to the ocean. It was such a beautiful
experience, the turtles can barely see, but can sense the sea. It’s
incredible how they gravitate toward the ocean! It’s best not touch them
if you are not wearing gloves as our bacteria can cause them illnesses.
We did meet a little guy with a leg that wasn’t fully formed, but that
didn’t stop him, he took longer than everyone else, but he made it!
As you explore the island you will also meet little deer-like animals,
the suni and ader dyker, both species of antelope. Being some of the
rarest in Africa, they are protected on the island and allowed to breed.
I was hoping to catch sight of the coconut crab but I don’t think he
wanted to see me.
The island seemed to have a micro climate. Mnemba had clear skies
everyday, while the main island of Zanzibar, just across from us, would
be cloudy and rainy, it was very strange but very special!
I can say so much more, but it would never do justice. Hopefully my
pictures show you the true magic of this island. I can’t wait to return!
So long Mnemba, till we meet again.
Dapiprazole (Rev-Eyes) is an alpha blocker. It is used to reverse mydriasis after eye examination.[1]
Used in the treatment of iatrogenically induced mydriasis produced by
adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents
used in certain eye examinations.
Dapiprazole is an alpha-adrenergic blocking agent. It produces miosis
by blocking the alpha-adrenergic receptors on the dilator muscle of the
iris. Dapiprazole produces no significant action on ciliary muscle
contraction and thus, there are no changes in the depth of the anterior
chamber of the thickness of the lens. It does not alter the IOP either
in normal eyes or in eyes with elevated IOP. The rate of pupillary
constriction may be slightly slower in clients with brown irises than in
clients with blue or green irises.
Dapiprazole acts through blocking the alpha1-adrenergic receptors in
smooth muscle. It produces miosis through an effect on the dilator
muscle of the iris and does not have any significant activity on ciliary
muscle contraction and, therefore does not induce a significant change
in the anterior chamber depth or the thickness of the lens.
Oral LD50 is 1189-2100 mg/kg in mice, rats and rabbits.
Brief background information
Salt
ATC
formula
MM
CASE
–
N05AX
S01EX02
C19H27N5
325.46 g / mol
72822-12-9
monogïdroxlorïd
N05AX
S01EX02
C19H27N5 · HCl
361.92 g / mol
72822-13-0
Application
antipsihoticheskoe means
in the treatment of glaucoma
Classes substance
Piperazinы
1,2,4-triazolo [4,3-a] piridinы
Synthesis
Синтез a)
Scheme illustration:By cyclization of
O-methylvalerolactam (I) with 3-(4-o-tolyl-1-piperazinyl) propionic acid
hydrazide (II) in refluxing xylene, followed by a treatment with
ethanolic HCl.
FR 2423221; GB 2020269; JP 54157576; NL 7902489; US 4252721
Acylation of (1-methylcyclopropyl)guanidine (IV) with
3-bromo-5-chlorothiophene-2-sulfonyl chloride (III) under
Schotten-Baumann conditions afforded the sulfonyl guanidine (V). This
was cyclized to the desired thienothiadiazine upon treatment with Cs2CO3
and Cu2O in boiling butanol.
In a different method, (1-methylcyclopropyl)guanidine (I) is acylated
by 3-bromo-5-chlorothiophene-2-sulfonyl chloride (II) to produce the
sulfonyl guanidine (III). Intramolecular cyclization of (III) in the
presence of Cu2O and Cs2CO3 leads to the title thienothiadiazine
derivative. Similarly, acylation of guanidine (I) with
3,5-dichlorothiophene-2-sulfonyl chloride (IV) provides sulfonyl
guanidine (V), which is then cyclized in the presence of Cu2O and
Cs2CO3.
In an alternative method, sulfonylation of N-isopropylguanidine (V)
with 2,5-dichlorothiophene-3-sulfonyl chloride (IV) produced the
sulfonyl guanidine (VI). This was then cyclized to the title compound by
treatment with copper bronze and potassium carbonate in boiling
DMF……..WO 0102410
Trade names
country
Tradename
Manufacturer
Germany
Remidrial
winegrower
Italy
Glamidolo
Angelini, 1987
Ukraine
no
no
Formulations
eyedrops 50 mg / 10 ml (5%) (hydrochloride)
References
DE 2 915 318 (Angelini; appl. 14.4.1979; I-prior. 18.4.1978).
HERE ARE MY 10 REASONS WHY YOU SHOULD PACK YOUR BAGS AND HEAD TO BURMA!
01: The People
For true hospitality, travel to Burma
In my travel experience, out of all the
Asians I have met, the Burmese are the kindest, most friendly people who
are willing to go above and beyond to make friends with you, help you
out and make sure you are having a great time in their country. They
always seem to be happy, smiling and keen to practice their English over
a glass of tea! They can be quite a shy people as they are extremely
polite, kids tend to be the exception to the rule – they will always run
up to you to practice their English and unlike the rest of Asia, I was
never once hassled by locals for money. The Burmese left a lasting
impression on me; I felt that I could truly trust them and I made some
incredible connections with locals I met whilst travelling there.
02: Insane Temple Ruins
Get lost in some of the biggest temple ruins in the world
When most people think of lost cities
they immediately think of Angor Wat in Cambodia or maybe Hampi in India
but the ruins of Bagan in central Burma are without a doubt the most
stunning, least touristey, ruins I have ever seen. I spent an incredible
few days exploring by bike, watching the sun set over Bagan’s temple
studded plains and making friends with the local kids out to practice
their English. For the true adventurer, you can head even deeper into
the country’s largely unexplored regions and visit the stunning temple
ruins at Mrauk Au, you will probably have them all to yourself.
03: Real Exploring
Discover the Asia of 100 years ago
Burma is an absolutely massive country
and there are many hidden gems in this astounding country which only the
locals will know about. It is extremely easy to get off the beaten
track and to have temples, ruins, mountains and caves all to yourself.
When backpacking in Burma, I felt like I had stepped back 100 years in
to the past, I felt like a proper explorer. The people who I met in
remote communities in the Shan highlands had often not seen another
westerner for months or even years, this is prime exploring territory.
Whilst exploring the south of the country I came across a huge field of
painted Buddha statues, some were cracked and covered by jungle, others
looked freshly painted. Who built, painted and maintained them? I have
no idea. This is why I love Burma.
04: Trekking
Take to the hills and meet awesome people
Trekking in Burma is a relatively new
activity but already tour agencies are springing up to cater for
adventourous backpackers. Most backpackers opt for a two day trek around
the stilt villages of Inle Lake but for a real experience; head deep
into the Shan highlands or South to Hp-Pan. Here you can summit jungle
clad limestone peaks, many of which are topped by small monastries, and
soak in some spectacular views. Trekking in Burma is a really amazing
experience; I met colourful freshwater crabs, hiked through mist draped
forests and shared tea with novice monks who spoke no English but always
seemed happy to see me.
Speaking of Monks, it’s pretty hard to
travel in Burma without meeting a few! I had some amazing discussions
with monks I met in temples, on buses, in the street or even whilst
riding my bicycle. I was told by a monk that 1% of Burma’s entire
population are monks and they certainly seem to be everywhere. Whilst
trekking I met a shy monk working on repairing a temple wall, we chatted
for a while and I spent an hour helping him, he offered me tea and
allowed me to take his photograph. I came away with a much richer
understanding of what Buddhism is all about. The monks are a friendly
bunch and would often ask me all kinds of questions about life outside
Burma, spirituality and even football!
06: Food
“Really? The food’s OK?” I hear you ask…
The food is better than OK, Burmese
cuisine is some of the best in Asia. Sure, there may not be many Burmese
restaurants outside of Burma but that’s largely because the country has
been shut off from the rest of the world for so long. The food is an
eclectic mix of Thai, Chinese and Indian cuisine and basically includes
all the best bits from Thai, Chinese and Indian dishes. Check these
tasty, one of a kind, dishes out:
– Gyin Thohk – tasty ginger salad with sesame seeds.
– Fruit Shakes – Keep an eye out for creamy avocado and banana shakes around Inle Lake
– Kat Kyi Hnyat – The Burmese answer to Pad Thai, a gorgeous coastal
dish of rice noodles with seafood, meats, raw bean sprouts and fried
eggs.
– Danbauk – A tasty Indian inspired curry served with mango pickle, fresh mint and green chili.
– Shan Tofu – Do not miss this awesome home-made tofu from the Shan highlands.
07: Cheap Beer!
Beer for 50 cents?!
I have made it a personal mission to
sample as many local beers throughout the world as I possibly can… so
far, Myanmar Beer is without a doubt my favourite brand. For just 50
cents, you can have a cool, refreshing, tap drawn beer in a iced glass.
For five bucks, you can get well and truly merry. Mandalay Beer makes a
tasty alternative if you get sick of Myanmar Beer but I can guarantee
you won’t.
08: Stunning Islands & Beaches
Burma has a hidden paradise of unexplored beaches and islands
Most Backpackers are not yet aware that
Burma has some of the world’s most beautiful beaches and islands. Until
recently, these palm-fringed, white sand playgrounds were off limits
unless you had a super-yacht handy but this is changing fast and every
week more and more restrictions are being lifted. Now is the perfect
time to travel to Burma and hunt for your dream island; think coral blue
waters, coconut cocktails and perfect sandy beaches, the opportunities
are endless. There are over 800 islands in Burma’s Mergui archipelago
which are currently empty, making this the perfect opportunity to head
out on a kayak or boat and discover paradise in the ocean.
09: Caves
Discover cavernous underground temples filled with Buddha images
When travelling, I’m always looking for adventurous ways to keep myself busy, whether it’s living in a cave with a Bedouin
or mountain biking through the jungles of Laos. In Burma, there is a
ton of activities for the adventurous traveller but one of the best has
got to be exploring some of the huge caves which pockmark the country.
Many of these are not covered by any guidebook, it’s simply a case of
asking around and seeing if there are any cool caves nearby. One of the
biggest which I visited, in the South of the country, was filled with
huge Buddha images and statues as well as some beautiful rock
formations. I walked through it for over an hour, it must have been
about three kilometres long, before I emerged on the other side to find a
hidden lake framed by a backdrop of limestone mountains; to this day it
is still one of the most beautiful things I have discovered whilst
backpacking.
Cave temples
Cave tunnels
The view from inside a huge cave
Inside the caves of Hp-Pan
10: It’s changing fast
Now is the time to go!
Burma is well and truly back on the
Backpacker map and in 2014 it has become THE place to go. I was lucky
enough to first visit in 2012 and I met perhaps a dozen backpackers in
my entire time there. These days, more and more backpackers are tagging
Burma on to the classic Thailand – Laos – Vietnam – Cambodia route, and
rightly so! However, as the country continues to open up and as
investment and travelers continue to pour in it is only a matter of time
before some of Burma’s most enchanting attractions become diluted.
Luckily, the country is so big that there is plenty of room and plenty
of wild places left for backpackers to explore. Do not hesitate; visit
this incredible land now, meet the wonderful people, have a beer or
three and explore till your heart’s content.
The Golden Rock
Friendly locals
A jungle crab I met trekking
Laying golden leaf on the Buddha
Epic temples
The Buddha and 500 Sanghas
Local kid in Hp-Pan
Inle Lake stilt villages
…AND NOW? PACK YOUR BACKPACK, BOOK YOUR FLIGHT AND GET OUT THERE!!
Need some more information? Check out this travel guide I wrote based on my travels in Burma.
///////Intensified, biocatalytic production, enantiomerically pure, halophenylalanines, acrylic acids, ammonium carbamate, ammonia source
.
