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Sunday 18 September 2016

Dipeptide (histidine-β- alanine)




Characterization of synthesised dipeptide (histidine-β- alanine) Dipeptide was successfully synthesized via the standard BOC method. The synthesis of dipeptide (histidine-β- alanine) was approved by using UV-Vis, FTIR, 1 H NMR and LC-MS analysis. The UV-Vis absorbance spectra of histidine-β-alanine obtained in water at 25 °C is presented in Figure 1. The results show that the maximum peaks were appeared at 214 and 264 nm, which can be assigned to π→π* and n→π*, respectively.
FTIR (KBr) n / cm−1 3226 (NH2), 1641 (amide), 1563 (imidazol);

1H NMR (300 MHz, D2O) d 2.60 (m, 2 Hs, 12H), 2.92 (dd, 1 Hs, 6H), 3.08 (dd, 1 Hs, 6H), 3.16 (m, 2 Hs, 11H), 4.40 (dd, 1 Hs, 7H), 6.89 (s, 1 Hs, 4H), 7.66 (dd, 1 Hs, 2H), 7.89 (imidazole ring).

The LC-MS analysis showed a single mass peak in [M + H]+ and [M]− , which
correspond to molecular weight for dipeptide calculated for C9H14N4O3: 226.23; found m/z [M + H]+ : 227.000 and m/z [M]− : 224.800 (Figure 2).












J. Braz. Chem. Soc. 2016, 27(10), 1814-1819

Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al3+, Cu2+, Hg2+ and Pb2+: Experimental and Theoretical Study


Rahmatollah Rahimi; Maryam Khosravi; Mohammd H. H. Tehrani; Mahboubeh Rabbani; Ebrahim Safavi



Rahimi R, Khosravi M, Tehrani MHH, Rabbani M, Safavi E. Solid-Phase Peptide Synthesis of Dipeptide (Histidine-β-Alanine) as a Chelating Agent by Using Trityl Chloride Resin, for Removal of Al3+, Cu2+, Hg2+ and Pb2+: Experimental and Theoretical Study. J. Braz. Chem. Soc. 2016;27(10):1814-1819



Solid-phase peptide synthesis of dipeptide (histidine-β-alanine) as a chelating agent examined. Trityl chloride resin was used as a carrier.

http://dx.doi.org/10.5935/0103-5053.20160064

Published online: March 1, 2016

*e-mail: rahimi_rah@iust.ac.ir



Department of Chemistry

 Dr. Rahmatollah Rahimi
  Professor, Inorganic Chemistry Division
  E-mail address: Rahimi_Rah@iust.ac.ir
  Office Tele: 77240290, 77240-50(2718)
  Fax: 77491204

  AWT IMAGE

  Academic Degrees:
  Bachelor of Science: Chemistry, Howard University, USA, 1983
  Master of Science: Physical chemistry, Howard University, USA, 1987
  Ph. D.: Inorganic Chemistry, Howard University, USA, 1991

 Active Research fields:
  - Synthesis and characterization of porphyrins and metalloporphyrins and Investigation of their applications.
  - Photocatalysis process
  - Preparation and characterization of solar cells
  - Invironmental projects
  - Bioinorganic chemistry
  Teaching Experiences:
  A) Teaching Courses at undergraduate level:
  -General chemistry
  -Inorganic Chemistry
  -Physical chemistry
  -Physical chemistry laboratory
  -General Chemistry laboratory
  -Chemistry science literature

  B) Teaching Courses at graduate level (MS):
  -The professional language for Chemistry
  -Inorganic kinetics and Thermodynamics
  -Physical Inorganic Chemistry
  -Research method
  -Advanced Inorganic Chemistry
  -Bio Inorganic Chemistry

  C) Teaching Courses at graduate level (PhD):
  -Advanced Bio Inorganic Chemistry
  -Structures and bonds of inorganic components
  - Organometallic Chemistry
  Research activities:
  A) Scientific Research articles :
  More than 175 Articles Published at Conferences and Journals

  Patent:

1. “Application of LED lamps for treatment and disinfection of wastewaters using nanophotocatalysts” Rahmatollah Rahimi, Javad Shokraian, Mahboobeh Rabbani, 1393
2. “Synthesis of ZnO Nanorods in low temperature via Coprecipitation Method” Rahmatollah Rahimi, Marzieh Yaghoubi Berijani, Solmaz Zargari, 1393

3. “Synthesis of BiVO4 photocatalyst with two monoclinic and tetragonal phases, active in visible and ultraviolet region”, Rahmatollah Rahimi, Marzieh Yaghoubi Berijani, Solmaz Zargari, 1393
   
4. “Synthesis of polypyrrole-iron oxide functionalized with porphyrin as an efficient sorbent of industrial pollutions”, Rahmatollah Rahimi, Meisam Asadi Davati, Solmaz Zargari, 1392

5. “ Synthesis of Titanium dioxide (TiO2)-Vanadium phosphorous nanocomposite oxidized with silver (Ag-VPO) as a catalyst (Ag-VPO/TiO2) and is organic pollution degradation under visible light illumination”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391

6. “ Synthesis of SbVO4-TiO2 nanocomposite as a catalysts and its investigation in degradation of organic pollutions under visible light irradiation”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391
7. “Synthesis of Titanium dioxide-Bismut vanadat (BiVO4-TiO2) sensitized with porphyrin (TCPP) and its photocatalytic application under visible light irradiation”, Rahmatollah Rahimi, Masoumeh Mahjoub Moghaddas, Solmaz Zargari, 1391

8. “Preparation ofV-TiO2-TCPP and its concurrent application in removal anddegradation of industrial pollutants”, Rahmatollah Rahimi, Masoumeh MahjoubMoghaddas, Solmaz Zargari, 1391
9. “Preparation of Vdoped TiO2 mesoporous and sensitized with porphyrin over SBA-15substrate”, Ahmad Najafian, Masoumeh Mahjoub Moghaddas, Rahmatollah Rahimi, 1391

10. “Preparation ofporphyrin on SBA-15 catalysts”, Mehdi Deilam Kamar, Ahmad najafian, RahmatollahRahimi, 1391.

11. “Nanoporous TiO2solar cell sensitized with tetra(4-carboxyphenyl)porphyrin”, RahmatollahRahimi, Pegah Tvakoli fard, 2010


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Devprayag, Uttarakhand, India

Map of Devprayag India
Devprayag
Town in India
Devprayag is a town and a nagar panchayat in Tehri Garhwal district in the state of Uttarakhand, India, and is one of the Panch Prayag of Alaknanda River where Alaknanda and Bhagirathi rivers meet and take the name Ganga or Ganges River. Wikipedia
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Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate






General procedure for the preparation of ten newly synthetized compounds - 2-(p-chlorophenyl)-3-methyl-4- (p-isopropylphenyl)-1,3-thiazolium-5-(N-arylacetamide)thio chloridrates 7a-j Mesoionic 2-(p-chlorophenyl)-3-methyl-4-(pisopropylphenyl)-1,3-thiazolium-5-thiolate 5 (278 mmol) was dissolved in hot ethanol and then 2-chloro-Narylacetamides 6a-j (278 mmol) were added. The system was refluxed for 4 h and then concentrated at reduced pressure, giving a yellow-orange solid.


R1, R2 =H, H
7a


2-(p-Chlorophenyl)-3-methyl-4-(p-isopropylphenyl)-1,3- thiazolium-5-(N-phenylacetamide)thio chloridrate 7a Yield: 92.13%;

m.p.: 130-132 °C; anal. calcd.: C, 60.58; H, 4.69; N, 5.43; S, 12.44; found: C, 60.60; H, 4.70; N, 5.42; S, 12.42;

IR (KBr) νmax / cm-1 3181 (NH), 3003 (CHAr.), 2958 (CHAlif.), 1680 (C=O), 1599, 1551, 1491 (C=C and C=N of aromatic and heterocyclic rings), 1442 (C–N of N–CH3), 1404 (C–N), 1092 (C–Cl), 1001, 922 (CHAr.), 756 (NH), 557, 537 (C–C);

1 H NMR (200 MHz, CDCl3) delta
1.30 (d, 6H, J 6.9 Hz, H-16, H-16’),
2.98 (sept, 1H, H-15), 3.79 (s, 2H, H-17),
3.84 (s, 3H, H-10), 7.09 (t, 2H, J 7.3 Hz, H-23),
7.28-7.34 (m, 4H, H-13, H-13’, H-21, H-25),
7.60 (d, 2H, J 8.1 Hz, H-8, H-8’),
7.73 (d, 2H, J 7.9 Hz, H-12, H-12’),
7.86-7.93 (t, 4H, J 7.3 Hz, H-7, H-7’, H-22, H-24),
11.02 (s, 1H, H-19);


13C NMR (50 MHz, CDCl3)
delta 170.21 (C-2), 166.81 (C-18), 152.68 (C-14),
140.28 (C-4), 138.93 (C-9), 132.04 (C-20), 131.64 (C-7, C-7’), 130.89 (C-12, C-12’),
130.27 (C-8, C-8’), 128.69 (C-22, C-24), 127.54 (C-13, C-13’),
124.09 (C-23), 123.79 (C-11), 123.59 (C-6),
120.28 (C-21, C-25), 42.24 (C-17), 40.92 (C-10), 34.21 (C-15), 23.76 (C-16, 16’).








Peixoto IN, Souza HDS, Lira BF, Silva DF, Lima EO, Barbosa-Filho JM, et al. Synthesis and Antifungal Activity AgainstCandida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate. J. Braz. Chem. Soc. 2016;27(10):1807-1813

*e-mail: athayde-filho@quimica.ufpb.br
J. Braz. Chem. Soc. 2016, 27(10), 1807-1813

Synthesis and Antifungal Activity Against Candida Strains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate


Isabelle N. Peixoto; Helivaldo D. S. Souza; Bruno F. Lira; Daniele F. Silva; Edeltrudes O. Lima; José M. Barbosa-Filho; Petrônio F. de Athayde-Filho

Ten new mesoionic derivatives from the 1,3-thiazolium-5-thiolate system with substituted acetamides were synthesized, had their potential as new drug evaluated in an in silico study and in their activity as antifungal against strains of Candida albicans.

http://dx.doi.org/10.5935/0103-5053.20160063

Published online: February 26, 2016
http://jbcs.sbq.org.br/imagebank/pdf/151131AR.pdf

Petrônio Filgueiras Athayde-Filho
Petrônio F. de Athayde-Filho
Universidade Federal da Paraíba

Universidade Federal da Paraíba
https://www.researchgate.net/profile/Petronio_Athayde-Filho

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Dubrovnik, croatia


Map of Dubrovnik
Dubrovnik
City in Croatia
Dubrovnik is a city in southern Croatia fronting the Adriatic Sea. It's known for its distinctive Old Town, encircled with massive stone walls completed in the 16th century. Its well-preserved buildings range from baroque St. Blaise Church to Renaissance Sponza Palace and Gothic Rector’s Palace, now a history museum. Paved with limestone, the pedestrianized Stradun (or Placa) is lined with shops and restaurants.


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Thursday 15 September 2016

2-Ethoxy-1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole


str2
2-Ethoxy-1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole



SCHEME
Figure
2-Ethoxy-1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazole (14)
A reactor was charged with compound 13 (500 g, 2.23 mol), compound 10 (595 g, 2.23 mol), sodium iodide (334 g, 2.23 mol), potassium carbonate (338 g, 2.45 mol), and water (3 L). Then the mixture was heated at reflux for 12 h. The reaction mixture was cooled to room temperature and extracted with ethyl acetate (2 L). The organic layer was washed with water (700 mL) and brine (500 mL), dried, and evaporated under reduced pressure to provide 14 which was used directly in the next step (857 g, 92%).

1H NMR (500 MHz, CDCl3) δ 7.56 (m, 1H), 7.32 (t, J = 8.0 Hz, 1H), 7.21–7.12 (m, 3H), 7.10 (brt, J = 1.9 Hz, 1H), 7.07 (d, J = 7.7 Hz, 1H), 7.02 (dd, J = 8.4, 2.4 Hz, 1H), 4.62 (q, J = 7.1 Hz, 2H), 4.11 (t, J = 6.8 Hz, 2H), 3.19 (brt, J = 5.0 Hz, 4H), 2.75 (t, J = 6.9 Hz, 2H), 2.66 (t, J = 5.0 Hz, 4H), 1.49 (t, J = 7.1 Hz, 3H).

13C NMR (125 MHz, CDCl3) δ 157.4, 151.3, 140.3, 133.6, 131.4 (q, J = 31.8 Hz), 129.6, 124.4 (q, J = 272.5 Hz), 121.5, 120.8, 118.7, 117.7, 115.9 (q, J = 3.9 Hz), 112.2 (q, J = 3.8 Hz), 108.1, 66.2, 56.4, 53.1 × 2, 48.6 × 2, 39.7, 14.9.

ESI-MS (m/z): 419.6 [M + H]+; HRMS (ESI) calcd [M + H]+ for C22H26F3N4O 419.2059, found 419.2071.

HPLC: retention time of 12.4 min, 95% purity.


str3
str1 



str2