DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Tuesday 3 March 2015

Dacomitinib

Dacomitinib

(2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}-4-(1-piperidinyl)-2-butenamide

4-Piperidin-1-yl-but-2-enoic acid [4-(3-chloro-4-fluoro-phenylamino)-7-methoxy-quinazolin-6-yl]-amide

1042385-75-0

pf299804…… pfizer

EGFR (HER1; erbB1) Inhibitors
HER4 (erbB4) Inhibitors
HER2 (erbB2) Inhibitors

Molecular formula:C24H25ClFN5O2
Molecular mass:469.95

syn.........http://newdrugapprovals.org/2014/04/09/dacomitinib-in-phase-3-for-lung-non-small-cell-nsclc-cancer/

1H NMR

COSY PREDICTION

1H NMR PREDICT
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide NMR spectra analysis, Chemical CAS NO. 1110813-31-4 NMR spectral analysis, (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide H-NMR spectrum

(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide NMR spectra analysis, Chemical CAS NO. 1110813-31-4 NMR spectral analysis, (E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide H-NMR spectrum

13 C NMR PREDICT

.....

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Dacinostat (LAQ-824, NVP-LAQ824,)

((E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1 H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide

(2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide

404951-53-7

C22H25N3O3

Exact Mass: 379.18959

Molecular Weight: 379.45

Novartis (Originator)

SEE MORE AT..........http://drugsynthesisint.blogspot.in/p/nostat-series.html

syn http://newdrugapprovals.org/2015/03/03/dacinostat-laq-824-nvp-laq824/

(E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide NMR spectra analysis, Chemical CAS NO. 404951-53-7 NMR spectral analysis, (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide H-NMR spectrum

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

Monday 2 March 2015

(S)—N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methylamino-propionamide hydrochloride

Example 17 (S)—N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methylamino-propionamide hydrochloride

5-Amino-1,3-dimethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one (Russian Journal of Organic Chemistry, 2007, 43, 11, 1706-1709) was treated with Boc-N-methyl-L-alanine according to the General procedure 4 (PyBop coupling) and the product of the reaction deprotected according to the General procedure 3 (HCl deprotection) to afford the title compound.

1H NMR (400 MHz, Me-d3-OD):

7.93 (1H, d),

7.48 (1H, d),

4.04 (1H, d), NHCH CH3C=0

3.45 (6H, s), TWO ARC-NCH3-C=O

2.77 (3H, s), NHCH3

1.64 (3H, d). NHCH CH3C=0

MS: [M+H]⁺=264.

see......http://www.google.com/patents/US20140045831

DRUG APPROVALS BY DR ANTHONY MELVIN CRASTO .....FOR BLOG HOME CLICK HERE

vietnam

dalat city

hanoi

//////////

Me

DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai), INDIA, worlddrugtracker, 29Yrs Exp. in the field of Organic Chemistry,Working for GLENMARK PHARMA at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational content...........P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent. सुकून उतना ही देना प्रभू, जितने से जिंदगी चल जाये। औकात बस इतनी देना,कि औरों का भला हो जाये।

ORGANIC SPECTROSCOPY INTERNATIONAL

Pages

Tuesday 3 March 2015

Dacomitinib

Dacomitinib

amcrasto@gmail.com

amcrasto@gmail.com

Dacinostat (LAQ-824, NVP-LAQ824,)

amcrasto@gmail.com

amcrasto@gmail.com

Monday 2 March 2015

(S)—N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methylamino-propionamide hydrochloride

amcrasto@gmail.com

amcrasto@gmail.com

Organic Chemistry Select

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1	New Drug Approvals ,	22.3	https://newdrugapprovals.org/	216 countries
	ORGANIC SPECTROSCOPY INTERNATIONAL	11.12	https://orgspectroscopyint.blogspot.in/
3	API SYNTHESIS INTERNATIONAL	2.81	http://apisynthesisint.blogspot.in/
4	ONE ORGANIC CHEMIST ONE DAY	3.14	http://oneorganichemistoneday.blogspot.in/
5	WORLD DRUG TRACKER	4.8	http://worlddrugtracker.blogspot.in/
6	MEDICINAL CHEM INTERNATIONAL	2.6	http://medcheminternational.blogspot.in/
7	ALL ABOUT DRUGS	2.1	http://www.allfordrugs.com/
8	DRUG PATENTS INTENATIONAL	2.46	http://drugpatentsint.blogspot.in/
9	Green Chemistry International,	0.14	https://greenchemclips.wordpress.com/
10	Drug regulatory affairs international	1.18	https://amcrasto.wordpress.com/
11	Organic Chemistry Select	0.69	https://anthonycrasto.wordpress.com/
12	ORGANIC CHEMISTRY INTERNATIONAL	2.17	http://organicchemistrysite.blogspot.in/
13	ORGANIC SYNTHESIS INTERNATIONAL	3.12	http://organicsynthesisinternational.blogspot.in/
14	DRUG APPROVALS INTERNATIONAL	1.1	http://drugapprovalsint.com/
15	Eurekamoments in Organic Chemistry ,	0.5	http://amcrasto.theeurekamoments.com/
16	WIX BLOG ,	0.2	http://amcrasto.wix.com/anthony-melvin-crasto/apps/blog
17	ALL FOR DRUGSON WEB,		http://amcrasto.webs.com/

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