(S)—N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methylamino-propionamide hydrochloride

 



Example 17 (S)—N-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-5-yl)-2-methylamino-propionamide hydrochloride

5-Amino-1,3-dimethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one (Russian Journal of Organic Chemistry, 2007, 43, 11, 1706-1709) was treated with Boc-N-methyl-L-alanine according to the General procedure 4 (PyBop coupling) and the product of the reaction deprotected according to the General procedure 3 (HCl deprotection) to afford the title compound. 

1H NMR (400 MHz, Me-d3-OD): 

7.93 (1H, d), 

7.48 (1H, d), 

4.04 (1H, d), NHCH CH3C=0

3.45 (6H, s), TWO ARC-NCH3-C=O

2.77 (3H, s), NHCH3

1.64 (3H, d).  NHCH CH3C=0

MS: [M+H]⁺=264.

see......http://www.google.com/patents/US20140045831







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