DR ANTHONY MELVIN CRASTO,WorldDrugTracker, helping millions, A 90 % paralysed man in action for you, I am suffering from transverse mylitis and bound to a wheel chair, With death on the horizon, nothing will not stop me except God................DR ANTHONY MELVIN CRASTO Ph.D ( ICT, Mumbai) , INDIA 25Yrs Exp. in the feld of Organic Chemistry,Working for GLENMARK GENERICS at Navi Mumbai, INDIA. Serving chemists around the world. Helping them with websites on Chemistry.Million hits on google, world acclamation from industry, academia, drug authorities for websites, blogs and educational contribution

Sunday 1 March 2015

Synthesis of 2-phenyl indoxyls

Synthesis of 2-phenyl indoxyls 

ARKIVOC 2006 (xi) 37-46 pp. 37 - 46 



Synthesis of 2-phenylindoxyls
Michael C. Hewitt* and Liming Shao
Drug Discovery, Sepracor Inc., 84 Waterford Drive, Marlborough MA 01752, USA
E-mail: michael.hewitt@sepracor.com
http://www.arkat-usa.org/get-file/23564/


Michael HewittMichael hewitt



Page image. To view text version select 'text' from the format menu.
Page image. To view text version select 'text' from the format menu.

10 a  n=1
10a: HPLC Rt = 9.87 min,

1 H NMR (400 MHz, CDCl3)
7.66-7.60 (m, 4H),
7.41-7.37 (m, 3H),
7.11-7.05 (m, 2H),
4.10-4.04 (m, 2H), NCH2
3.69-3.63 (m, 1H), 1H OF OCH2
3.58-3.51 (m, 1H); 1H OF OCH2


13C NMR (100 MHz, CDCl3) 197.2,C=0,  163.9, 137.8, 136.0, 128.9, 128.4, 126.5, 125.7, 122.8, 122.6, 114.8, 99.6, 67.9, 50.1;




http://www.nmrdb.org/13c/index.shtml?v=v2.14.1  PREDICT 13 C NMR

http://www.nmrdb.org/cosy/index.shtml?v=v2.14.1 COSY



GC-MS 13.4 min, M+ 251.

Selected gHMBC couplings (see above): 200 → 7.62, 7.64; 164 → 3.65, 3.5, 7.64; 99 → 3.65, 4.05.



1H NMR PREDICTION BELOW



Michael HewittMichael hewitt

No comments:

Post a Comment