| Methyl 2-amino-4-(trifluoromethyl)benzoate |
| 61500-87-6 CAS | |
| Synonyms: |
|---|
1H NMR (DMSO-d6) δ 3.79 (s, 3h), 6.75 (dd, j=1.84, 8.46 hz, 1H), 6.96 (br s, 2h), 7.11 (d, j=0.73 hz, 1H), 7.83 (d, j=8.09 hz, 1H)
13 C NMR PREDICT
COSY PREDICT
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SYNTHESIS
Hill; Stanley; Karoglan Williams; Loev; Fowler; McCafferty; Macko; Berkoff; Ladd Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 865 - 869
ELI LILLY AND COMPANY Patent: WO2006/2342 A1, 2006 ; Location in patent: Page/Page column 55-56 ;
European Journal of Medicinal Chemistry, , vol. 40, # 9 p. 897 - 907
https://www.google.com/patents/WO2006002342A1?cl=en
Add a solution of methyl 2-nitro-4-trifluoromethylbenzoate (106 g, 425 mmol) in ethyl acetate (2.2 L) to a slurry of 10% palladium on carbon (11.0 g) in ethyl acetate (200 mL) and stir the suspension at room temperature under an atmosphere of hydrogen at 60 psi for 3 h. Filter the suspension through a pad of Celite® and wash the pad with additional ethyl acetate. Remove the solvents under reduced pressure and purify the residue by column chromatography on silica gel, eluting with isohexane/ethyl acetate (9:1), to provide the title compound as a white crystalline solid (84 g, 95%).
1H NMR (300 MHz, CD3OD)
δ 7.93 (d, / = 8.48 Hz, IH),
7.06 (s, IH),
6.78 (s, IH),
4.86 (s, 3H), NH2 MAYBE
3.89 (s, 3H).
https://www.google.com/patents/WO2006002342A1?cl=en
Preparation of Methyl 2-amino-4-trifluoromethylbenzoate.
1H NMR (300 MHz, CD3OD)
δ 7.93 (d, / = 8.48 Hz, IH),
7.06 (s, IH),
6.78 (s, IH),
4.86 (s, 3H), NH2 MAYBE
3.89 (s, 3H).
If the products you look for are not in our catalog we would be pleased to offer our custom synthesis service. 1-decyl-2,3-dimethylimidazolium bis((trifluoromethyl)sulfonyl)imide
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