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Tuesday 3 November 2015

HCV NS5A Inhibitor from Theravance, Inc. to treat hepatitis C virus infection


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Figure imgf000003_0001
((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarbamoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester
N-​[(1S)​-​1-​[[(2S)​-​2-​[5-​[4'-​[[[6-​[(2R,​5S) ​-​2,​5-​dimethyl-​4-​[(methylamino)​carbonyl]​-​1-​piperazinyl]​-​3-​ pyridinyl]​carbonyl]​amino]​-​2'-​(trifluoromethoxy)​[1,​1'-​biphenyl]​- ​4-​yl]​-​1H-​imidazol-​2-​yl]​-​1-​pyrrolidinyl]​carbonyl]​-​2-​methylpropyl]​-​, Carbamic acid, methyl ester
Carbamic acid, N-​[(1S)​-​1-​[[(2S)​-​2-​[5-​[4'-​[[[6-​[(2R,​5S) ​-​2,​5-​dimethyl-​4-​[(methylamino)​carbonyl]​-​1-​piperazinyl]​-​3-​ pyridinyl]​carbonyl]​amino]​-​2'-​(trifluoromethoxy)​[1,​1'-​biphenyl]​- ​4-​yl]​-​1H-​imidazol-​2-​yl]​-​1-​pyrrolidinyl]​carbonyl]​-​2-​methylpropyl]​-​, methyl ester
CAS 1374883-22-3, 819.87, C41 H48 F3 N9 O6
Theravance, Inc.  INNOVATOR
To treat hepatitis C virus infection


  • ((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarbamoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (compound 1):
  • Figure US20130295048A1-20131107-C00001
    Recent estimates place the number of people infected with the hepatitis C virus (HCV) worldwide at more than 170 million, including 3 million people in the United States. The infection rate is thought to be roughly 4 to 5 times that of the human immunodeficiency virus (HIV). While in some individuals, the natural immune response is able to overcome the virus, in the majority of cases, a chronic infection is established, leading to increased risk of developing cirrhosis of the liver and hepatocellular carcinomas. Infection with hepatitis C, therefore, presents a serious public health problem.
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