.
Protected arginine thioacid enables convenient N-acylation with no detectable racemization. We report efficient syntheses of potentially biologically active arginine conjugates and novel arginine-containing di-, tri- and tetrapeptides in good yields without loss of chiral integrity.
DOI: 10.1039/C4RA04897K
http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra04897k#!divAbstract
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Protected arginine thioacid enables convenient N-acylation with no detectable racemization. We report efficient syntheses of potentially biologically active arginine conjugates and novel arginine-containing di-, tri- and tetrapeptides in good yields without loss of chiral integrity.
Arginine thioacid in synthesis of arginine conjugates and peptides
*Corresponding authors
aCenter for
Heterocyclic Compounds, Department of Chemistry, University of Florida,
Gainesville, USA
E-mail: ravilx84@gmail.com, charlesdennishall@gmail.com
Tel: +1-352-392-0554
E-mail: ravilx84@gmail.com, charlesdennishall@gmail.com
Tel: +1-352-392-0554
bCenter of
Excellence for Advanced Material Research, King Abdulaziz University,
Jeddah, Saudi Arabia
c
Department of Chemistry, King Abdulaziz University, Jeddah, Saudi Arabia
RSC Adv., 2014,4, 55210-55216
DOI: 10.1039/C4RA04897K
http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra04897k#!divAbstract
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L-arginine is found in red meat, poultry, fish, and dairy products. It can also be made in a laboratory and used as medicine. L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain, high blood pressure, and coronary artery disease.
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