Lewis acid-catalyzed 2-arylquinazoline formation from N′-arylbenzimidamides and paraformaldehyde

2-phenylquinazoline (2a, CAS: 25855-20-3)[2]

1 H NMR (400 MHz, CDCl3, ppm) δ 9.48 (s, 1H), 8.63-8.60 (m, 2H), 8.11-8.09 (m, 1H), 7.95-7.89 (m, 2H), 7.64-7.60 (m, 1H), 7.57-7.49 (m, 3H);

13C NMR (100 MHz, CDCl3, ppm) δ 161.1, 160.5, 150.8, 138.0, 134.1, 130.6, 128.6, 128.6, 128.6, 127.2, 127.1, 123.6 ;

MS (EI) ) m/z (%) 206, 197, 179, 105 (100), 77.

Wang, H. M.; Chen, H.; Chen, Y.; Deng, G. J. Org. Biomol. Chem. 2014, 12, 7792

2-phenylquinazoline

Lewis acid-catalyzed 2-arylquinazoline formation from N[prime or minute]-arylbenzimidamides and paraformaldehyde

Green Chem., 2016, Advance Article
DOI: 10.1039/C6GC02319C, Communication

Xiufang Cheng, Huamin Wang, Fuhong Xiao, Guo-Jun Deng
An efficient procedure for the synthesis of 2-arylquinazolines from N[prime or minute]-arylbenzimidamides has been developed under transition-metal-free conditions.

An efficient procedure for the synthesis of 2-arylquinazolines from N′-arylbenzimidamides has been developed under transition-metal-free conditions. In this process, stable and low-toxicity paraformaldehyde was used as the carbon source. A broad range of functional groups were well tolerated in this reaction system.

Lewis acid-catalyzed 2-arylquinazoline formation from N′-arylbenzimidamides and paraformaldehyde

Xiufang Cheng,^a   Huamin Wang,^a   Fuhong Xiao*^a and  Guo-Jun Deng*^a  

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Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China
E-mail: gjdeng@xtu.edu.cn, fhxiao@xtu.edu.cn
Fax: (+86)0731-5829-2251
Tel: (+86)0731-5829-8280

Green Chem., 2016, Advance Article

DOI: 10.1039/C6GC02319Chttp://pubs.rsc.org/en/Content/ArticleLanding/2016/GC/C6GC02319C?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

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